ID A0A8T2MPN8_9TELE Unreviewed; 1179 AA.
AC A0A8T2MPN8;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=Platelet-derived growth factor receptor alpha {ECO:0000256|ARBA:ARBA00016938};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE AltName: Full=Alpha platelet-derived growth factor receptor {ECO:0000256|ARBA:ARBA00030503};
DE AltName: Full=Alpha-type platelet-derived growth factor receptor {ECO:0000256|ARBA:ARBA00029782};
DE AltName: Full=Platelet-derived growth factor receptor-like protein {ECO:0000256|ARBA:ARBA00019671};
GN ORFNames=JZ751_027623 {ECO:0000313|EMBL:KAG9330015.1};
OS Albula glossodonta (roundjaw bonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Albuliformes; Albulidae; Albula.
OX NCBI_TaxID=121402 {ECO:0000313|EMBL:KAG9330015.1, ECO:0000313|Proteomes:UP000824540};
RN [1] {ECO:0000313|EMBL:KAG9330015.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HI-2016 {ECO:0000313|EMBL:KAG9330015.1};
RA Pickett B.D.;
RT "Applications of and Algorithms for Genome Assembly and Genomic Analyses
RT with an Emphasis on Marine Teleosts.";
RL Thesis (2021), BYU ScholarsArchive, Provo, UT, USA.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00051243};
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000256|ARBA:ARBA00011360}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG9330015.1}.
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DR EMBL; JAFBMS010000796; KAG9330015.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T2MPN8; -.
DR OrthoDB; 9936425at2759; -.
DR Proteomes; UP000824540; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0001667; P:ameboidal-type cell migration; IEA:UniProtKB-ARBA.
DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR FunFam; 2.60.40.10:FF:000720; Platelet-derived growth factor receptor alpha; 1.
DR FunFam; 3.30.200.20:FF:000025; Platelet-derived growth factor receptor alpha; 1.
DR FunFam; 2.60.40.10:FF:000223; Platelet-derived growth factor receptor beta; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042495; PDGFRL.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR PANTHER; PTHR15360:SF5; PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF25305; Ig_PDGFR_d4; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000824540};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1179
FT /note="Platelet-derived growth factor receptor alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035795607"
FT TRANSMEM 914..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 116..183
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 194..296
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..400
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 418..503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 617..696
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 701..796
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 982..1179
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 375..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1016
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1179 AA; 130582 MW; A2FBCD98B00FBF8C CRC64;
MDTLKTCLAL EIVLLGMLSG FQTVTSSRPT IVPDTREVVI EKHSRFNVSC TGSSEVAWTG
PEYDNIIFVQ TDFHTKTLII DNASAENTGF YTCEYKTPSG DAMEEEAEIY IFVPDPEVPF
VPEAAYGSQV PTDINENVIP CRVTNPKSHV VLWRADTGAE VAGLYDSTLG FIGNFSAGHY
VCQTIANGVV TDSPTYTVDN LRESSDFHVD VRASHVSVRA GDPFNISCLA PTGPFYEQQW
SHPRKQAEHA DQLKQVFGHS TVYTLKVAKA ALQDGGEYEC SIIHSLRGVS RTQRVTVTVY
PAGSFLSLQH GLAAVEFAEL LEERLFQVNI HAHPAPSVTW LKDGTPIDDH GHDVFSKTIH
IEGIRYQSTL TLTRPTEEDS GNYTISASSD SSSPASAHFS FLLRVKTPSR ALLPLQSPEI
SPAREDMVVP LHSSFQLSCR GEAELLWDTP LLQAPDWEGP VEDNSGLFVS SITVGNATAA
HTGFYTCYYA SSNSTEDELE ESSIYVYVPD PNVPFVPSVI PYANHVLSDQ EEMEIQCRVT
DPSANVTLLN IDTQRVVPSL YDSKRGAVGF FSSGTYVCRA VLSGQEHLSE EYIVHGWTGG
SGLQVDLQAS RAALLVGESL VVTCVARGSE MLEDLWKYPG KMAQRGVKTV RENKKEQEIR
YTLTIPQAST KDSGIYACSI TDIMSSDTQT KEVTVTVYER PFVSLTPMFT HSQFAELDEV
KEFGIIIDTY PAARVTWLKG GAVLSDISAE ITSSLQQISA TRYRSVLRLI RAKEEDSGNY
SIRVENGNQT QSFNFSLQVK VPVEIVNLME LHHGSSSGES VVCISRGRPI PEVEWYTCSS
IKQCANDSSR WIRLPVNSSD ITVETHINED NNLESQVIFA KLDSTLSVRC LARNELANAS
REVKLVSNAL QSELTVAAAV LVLLVIVIVS LIILVVIWKQ KPRYEIRWRV IESISPDGHE
YIYVDPMQLP YDSHWEFPRD GLVLGRVLGS GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP
TARSSEKQAL MSELKIMTHL GPHLNIVNLL GACTKSGPIY IITEYCLHGD LVNYLHKNRE
RFLSRNPEKV KKELDIFGLD PADQSSRSYV ILSFESKGDY MDMKQADGTQ YVPMLELSDA
SKYSHVQENY DRPPSHKHKS LSGELHPLCP RKSNSELTL
//
