ID A0A8T2N8P3_9TELE Unreviewed; 1400 AA.
AC A0A8T2N8P3;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=WD repeat and HMG-box DNA-binding protein 1 {ECO:0000256|ARBA:ARBA00069769};
DE AltName: Full=Acidic nucleoplasmic DNA-binding protein 1 {ECO:0000256|ARBA:ARBA00080131};
GN ORFNames=JZ751_003057 {ECO:0000313|EMBL:KAG9336709.1};
OS Albula glossodonta (roundjaw bonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Albuliformes; Albulidae; Albula.
OX NCBI_TaxID=121402 {ECO:0000313|EMBL:KAG9336709.1, ECO:0000313|Proteomes:UP000824540};
RN [1] {ECO:0000313|EMBL:KAG9336709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HI-2016 {ECO:0000313|EMBL:KAG9336709.1};
RA Pickett B.D.;
RT "Applications of and Algorithms for Genome Assembly and Genomic Analyses
RT with an Emphasis on Marine Teleosts.";
RL Thesis (2021), BYU ScholarsArchive, Provo, UT, USA.
CC -!- FUNCTION: Core replisome component that acts as a replication
CC initiation factor. Binds directly to the CMG complex and functions as a
CC hub to recruit additional proteins to the replication fork.
CC {ECO:0000256|ARBA:ARBA00056293}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG9336709.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAFBMS010000102; KAG9336709.1; -; Genomic_DNA.
DR OrthoDB; 427368at2759; -.
DR Proteomes; UP000824540; Unassembled WGS sequence.
DR GO; GO:0043596; C:nuclear replication fork; IEA:TreeGrafter.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:TreeGrafter.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd21993; HMG-box_WDHD1; 1.
DR CDD; cd00200; WD40; 1.
DR FunFam; 1.10.750.20:FF:000002; Suppressor of cytokine signaling 2; 1.
DR FunFam; 1.10.30.10:FF:000028; WD repeat and HMG-box DNA-binding protein 1; 1.
DR FunFam; 2.130.10.10:FF:001715; WD repeat and HMG-box DNA-binding protein 1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR055339; HMG-box_WDHD1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR057646; WD40_WDHD1_1st.
DR InterPro; IPR022100; WDHD1/CFT4_beta-prop_2nd.
DR InterPro; IPR048591; WDHD1/CFT4_hel.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF20946; Ctf4_C; 1.
DR Pfam; PF24815; HMG_WDHD1; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR Pfam; PF24817; WD40_WDHD1_1st; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000824540};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 252..347
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 342..391
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REPEAT 406..438
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 529..570
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 630..664
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1291..1359
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1291..1359
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1163
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 155015 MW; C85EB9644513FFE3 CRC64;
MNSGKAEMSE KKSRNSDTRP KCIRSWSADS YAWSNKKRSR SAHNEMGVSS TEGEGSEDQA
GRSASCPRRR RERKCSCATL GEGDTELPCR KALTRRSLRQ KFQDAVGQCF PLRTHHHHHH
HHHHHHQAGA SRPFSVLLWS KRKIHVSELM QDKCPFSPKS ELAHCWHLIK KHVSQSGNSI
SVAAEHKGSS CPSSSFSSTP PLISWEEISS GGTQGGSLDD WDPSRPGERA QGCSHTDYIL
VPDLLQINNS PCYWGVLDRF EAEELLEGQP EGTFLLRDSA QDEFLFSVSF RRYSRSLHAR
IEQNGKRFSF DGRDPCVYRD PSVTGLLKHY SDPATCLFFE PLLSRPLPRN FPFSLQHLCR
AVICSCTTYQ GIEALPLPHP LRDYLRQYHY KCNGACKMPA ERKPMRYGHS EGHTDVCFDD
TGKYIVTSGS DGDVRIWESL DDDDPKSINV GEKVHSLALM SGKLVTAVSN NTVQIHTFPE
GDPDGILTRF TTNANHVTFN SIGSRVAAGS SDFMVKVVEV SDSSQQKTLR GHDGPVLSVA
FDPNDEFLGS SSCDGTVAVW KIEDQVQVSN WKILQKSNDI SNAKSLCRLA WQPGRAKLLA
VPLDTTVQLY ERDSWNHVGT LSDDFITHPV NVVTWSPCGK FLAAGTIGGF LTVWDVETKL
CVEREKHEKG YTVCGLAWHP SGGQIAYTDT EGCLGLLDGV SASSSSSAST KSSNKVNVAS
VKLGSDKFGD DDGGSTILPA VTPAVPRPIY EGPMPTPPQK PFQPGSTPSH LMHRFMVWNS
VGIVRGYNDE QDNAIDVEFH DTAVHHAMHL TNSLGHSLAD LSQEAVLLAC EATDELASKL
QCLHFSSWDT NKEWMVDLPK GEEVKALCLG QGWAAAATST QLVRVFSIGG VQREVFCLPG
PVVCMAGHGE QIVIVYHRGT GFDGEQALGI QLLNFGLKKR QVIHGEPLSL SKKSYLSWLG
FTAEGTPCFV DSEGVVRMLN RSLGNTWTPV CNTRENCKGK SDHNWVVGVH ENPQQLRCIP
CKGSRFPPTL PRPAVTILPF KLPLCQTTTE KGQMEEQYWR SVLFHNHFDF LSSSGYEIDE
EAKNQAQKEQ QELLMKMFAR LSELALEKAA IEQRGEEQEE EELEYASAMR ASGYSRAAGE
RGESRQWSLR ESQEEEACEE EDGQQQMDTV EAVESRKASS KEGRVNPFKV SGTGKPNGLS
SGQPRVSNVL DTMTASGRKP SLMGNSGAKQ SKGPVLKPLV PRPKSKATLL QMGSSRVASK
RQEEREPAPQ PERQRNTDGG SPAPLSDNSE NRKPKTGFQL WLEENRKSIL ADNPDLDETD
VVKEAMGRFR ALSAEDRLTW TDRAKGGQLP EVADLKKRKR EDDESEEGAN NGQNERENSL
KKKKPLDATA KLSAFAFNKD
//
