ID   A0A8T2NMU5_9TELE        Unreviewed;      1113 AA.
AC   A0A8T2NMU5;
DT   12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT   12-OCT-2022, sequence version 1.
DT   10-JUN-2026, entry version 11.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=JZ751_024298 {ECO:0000313|EMBL:KAG9338908.1};
OS   Albula glossodonta (roundjaw bonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Albuliformes; Albulidae; Albula.
OX   NCBI_TaxID=121402 {ECO:0000313|EMBL:KAG9338908.1, ECO:0000313|Proteomes:UP000824540};
RN   [1] {ECO:0000313|EMBL:KAG9338908.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HI-2016 {ECO:0000313|EMBL:KAG9338908.1};
RA   Pickett B.D.;
RT   "Applications of and Algorithms for Genome Assembly and Genomic Analyses
RT   with an Emphasis on Marine Teleosts.";
RL   Thesis (2021), BYU ScholarsArchive, Provo, UT, USA.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAG9338908.1}.
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DR   EMBL; JAFBMS010000060; KAG9338908.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A8T2NMU5; -.
DR   OrthoDB; 9994905at2759; -.
DR   Proteomes; UP000824540; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13319; PH_RARhoGAP; 1.
DR   CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR   FunFam; 1.10.555.10:FF:000025; Rho GTPase-activating protein 20; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR   InterPro; IPR047887; ARHGAP20_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23179:SF36; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR   Pfam; PF22286; RHG20_PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00172}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000824540}.
FT   DOMAIN          345..517
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          686..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          836..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        692..706
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        836..848
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1113 AA;  123973 MW;  0339153505F243D7 CRC64;
     MTPQQNNDPH FKKDNDELKL RIEEREKAKN EDNGSEATVH SFSHYKSSQQ IKVPEQDVTQ
     HNPEVCNVAF SNEFLPLFGC GVLPSRDGGT GVHRNRSLIQ AFVSQSSSFI MDEQVHLTTG
     LQTQERHLFL FSDTLIIAKT KSSSSLKLKQ QVRLSEMWLA SCVEEVAERK LSSETSFVIG
     WPTTNYVVTL RNITKLKCDE YPHKISWKMM VLGVGNSILG SLTDYHLWVI SGKEEAPYPL
     IGHELPFSII MSSLRDAADQ PCLANNNVLT PDGTLALDQL PKGGNHVQFI LKLRPAARSH
     IRADSFQKHF KRKKSLIDWA LRRGNGSQST GQLDTPTTPR KLFGHSLSSI CHDGNLPKPI
     MDMLYLLYQE GPTTKGIFRR SANAKTCKEL KERLNAGDAV QMEGESVFVA ASVITLYSKW
     MEVTEINNTE EKIKEIKRLL DDLPDANVTL LRHLFGLLHH IQNNSEENQM NAFNLALCIS
     PNMLWLPVPA GPEEESKSTR KVARLIQFLI ENSPSIFDED FESLFTHLQS DQRPVEDVID
     ESFHQLYSSD ECDSEQDRFR RLPSLERDSF FLPLNDLVLT EETEIWSLLD EMDSFKKQHL
     MEDGGYSCGN LDNMSFRSDG SICSLVGTQD IESSRGRCSS EPSVCVSSQL LPQLHAPVAR
     QSSCDAAVMR CQTDGAQQGH KLCVDSARGA KGNTSPRTGS RSKYTSWRSP QITSRFKHAT
     HRVALSNRSS FSSLSSTATT PSASSLSSLD SALSYCSDSV FSPTDGASLP FLLGPSARVR
     PLTPDVSGGF STEWSRTLPA SLGREPCNLD WCNEYDENDE ENNVSGGKIA DIASILTSES
     DQSPTSCPGS WGAEERDPGQ DPGSDTDGAE RNASDSKVAD LQIHLPNEMS GTCQPKHQSR
     ETAFKHIQLT RPNSLELKKE RVKRTKITFY MASNTVAVRR QTDPNMKQHD HSVVEPNANA
     GSLDSSDQEC QMVQVHIPQT VFYGQDAPLV LQSVVARNPS SPKQQCRQVK TDVDGVPLSE
     QLTEGSSALP SPAKTNTKTT NSIRHTIRIR LPAAVRNTVK EYFNHSDNKN SLSEAKAVEK
     ELVRSKLEWQ KKNLMEEAKE SFVNLPFGEE SFV
//