ID A0A8T2P763_9TELE Unreviewed; 558 AA.
AC A0A8T2P763;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=JZ751_011157 {ECO:0000313|EMBL:KAG9344487.1};
OS Albula glossodonta (roundjaw bonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Albuliformes; Albulidae; Albula.
OX NCBI_TaxID=121402 {ECO:0000313|EMBL:KAG9344487.1, ECO:0000313|Proteomes:UP000824540};
RN [1] {ECO:0000313|EMBL:KAG9344487.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HI-2016 {ECO:0000313|EMBL:KAG9344487.1};
RA Pickett B.D.;
RT "Applications of and Algorithms for Genome Assembly and Genomic Analyses
RT with an Emphasis on Marine Teleosts.";
RL Thesis (2021), BYU ScholarsArchive, Provo, UT, USA.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG9344487.1}.
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DR EMBL; JAFBMS010000020; KAG9344487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T2P763; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000824540; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000824540};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 403..498
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 493..542
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 91..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..325
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 61508 MW; C1677402C67AC18E CRC64;
MWSNLKSRCQ TLFHQEGAGR SEGGEVSSVR CVVDPGRGLR LGEPLGPRAA SPAHSLSPLP
LVADSLQGPS RRGHNCVSDI PQIVEITIDK ESEDVRGPGG APLARRDSYS RHAPWGGKKK
HSCSTKTQSS LETDKRLGRS RGGLPRRERR YGVSSVHDMD SCAGRGGPGA RSLRQRIHDT
VGLCLPLRPR PRSSKALFTS KRKIHLTELM LETCPFPPGS DLAHKWHLIK QHTAPVSPQS
STTLLDAFDS ARPSPEDEEE RLRERRRLSI EEGVDPPPNA QIHTFEATAQ VSSLYKLGPK
MAPGMGEGSG EGKGGGSGGL GGAGASGASA LVTGAAAMPA PQPVDCDSEE DSTTLCLQSR
RPKQRHTSGD GHLSRQGPWK VHTQIDYIHC LVPDLLQITG LPCYWGVMDR YEAEALLEGK
PEGTFLLRDS AQEDYLFSVS FRRYNRSLHA RIEQWNHNFS FDAHDPCVFH ASTVTGLLEH
YKDPSSCMFF EPLLTAPLHR TFPFSLQHLA RAAICRRTTY DGIGGLPLPS TLQDFLKEYH
YKQKVRVRWL EREPLKIK
//
