ID A0A8T9AZ78_9HELO Unreviewed; 904 AA.
AC A0A8T9AZ78;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE SubName: Full=mRNA decapping complex subunit 2 {ECO:0000313|EMBL:TVY12994.1};
GN Name=dcp2 {ECO:0000313|EMBL:TVY12994.1};
GN ORFNames=LARI1_G008349 {ECO:0000313|EMBL:TVY12994.1};
OS Lachnellula arida.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Lachnaceae; Lachnellula.
OX NCBI_TaxID=1316785 {ECO:0000313|EMBL:TVY12994.1, ECO:0000313|Proteomes:UP000469559};
RN [1] {ECO:0000313|EMBL:TVY12994.1, ECO:0000313|Proteomes:UP000469559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 203.66 {ECO:0000313|EMBL:TVY12994.1,
RC ECO:0000313|Proteomes:UP000469559};
RA Giroux E., Bilodeau G.;
RT "Whole genome sequencing for identification of molecular markers to develop
RT diagnostic detection tools for the regulated plant pathogen Lachnellula
RT willkommii.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TVY12994.1}.
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DR EMBL; QGMF01001163; TVY12994.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8T9AZ78; -.
DR OrthoDB; 18996at2759; -.
DR Proteomes; UP000469559; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:TreeGrafter.
DR GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR FunFam; 1.10.10.1050:FF:000003; Decapping enzyme Dcp2, putative; 1.
DR FunFam; 3.90.79.10:FF:000003; M7GpppN-mRNA hydrolase isoform 2; 1.
DR Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR007722; DCP2_BoxA.
DR InterPro; IPR036189; DCP2_BoxA_sf.
DR InterPro; IPR044099; Dcp2_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF05026; DCP2; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM01125; DCP2; 1.
DR SUPFAM; SSF140586; Dcp2 domain-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000469559};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 95..227
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 369..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..392
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..755
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 98632 MW; A6B5D2C36FCBF71D CRC64;
MTETNLKLEE WLDDLCVRFI INLPEDDLKD IPRICFQVEE AQWYYEDFIR ALDPSLPSMS
LRNFCLRIFA HCPLLSSFSQ GHHMRAFEDF LAYKTRVPVR GAVMLNANMD SVVLVKGWKK
GASWSFPRGK IAKDEDDLTC AIREVYEETG FDLDAAGLVP PNRDVKSIQV NMREQQMRLF
VFRNVPMETH FEPKTRKEIS KIDWWQLSEL PAFRKKSQQQ QQKQAVPNSS KFYMVAPFLV
PLRKWVIEQK KKDARRTTSN QYLPAGMSHD EFLTEEDQGA ESATQMPYEE PSALELDTLE
GATTALSRLL KIQPATQGLQ AEAATQSSSK NSGEALLALL KPAASSQSLP ANAPPHTPLE
HIVMQPAMPK TPHHQQPRPP HFSNMPPPPD FPIQPQDDSF SHREANHQNG RHNAAEFQQS
HVGRQNPPRP QENPHSYQPQ HLIHPQPLPP HVQRALFTGG SVHSPMVPQS IQQNPPPVHT
AISGPTGAPQ FPALHATMVP QTVQQTPKLT SHSLALLNAF KTRDQAADEV SGSNDLPLRR
YTQAQNQASV PAPRGVPQEL PAEGSQPGQM LPPPQIKVQQ NVGHLTPTPL APRQSISATQ
KSTLLDLFRS PTAQPASLAN SAGATSLPIS TTPSVVELSA VEPLSTGAST TSALLNSKRT
PDNLASNGAV PVLNPESNLP FGAVSILGRP PNMSDKQSLS AAGSELDSKP KSNGKKPTAR
MNTGSHTVKL PEKPFQPQIL KRPQQSSSKT QQSPPAIQSG VSSFASQPGA SRMQQSPTPV
SPSSNFRSSQ GSLRMPHSAT AIQHPVSTFV PPPDRRPSQA VGHKQNLLSL FGKAQVGPIS
PPGRDGPSME PLASTVKTSV RSRVGSLASG GDGTSRRGSQ TPISPADKGF LLGYLEEALA
KGSR
//
