ID A0A8U0PEE0_SALNM Unreviewed; 398 AA.
AC A0A8U0PEE0;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=Suppressor of cytokine signaling 4-like {ECO:0000313|RefSeq:XP_038822951.1};
GN Name=LOC120023069 {ECO:0000313|RefSeq:XP_038822951.1};
OS Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salvelinus.
OX NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038822951.1};
RN [1] {ECO:0000313|RefSeq:XP_038822951.1}
RP IDENTIFICATION.
RC TISSUE=White muscle {ECO:0000313|RefSeq:XP_038822951.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_038822951.1; XM_038967023.1.
DR AlphaFoldDB; A0A8U0PEE0; -.
DR GeneID; 120023069; -.
DR KEGG; snh:120023069; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000808372; Chromosome 28.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 252..347
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 342..391
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 30..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44858 MW; 087837995CFF2815 CRC64;
MSEKKSRSSD ICPKCGIRSW SADSYVWSCK KRSRSSRNDP GLRGPEGVGP MEEQGARSTS
CLRRRGERRC SCTVMGEVDI DVPCRKALSR RSLRQKFQDA VGQCFPLRTD HHHHHHGCPT
GAYRGGFSVL LWSKRPIHVT ELMQDMCPFS SKSELAHCWH LIKKHATHPS AIVGLEVAQA
AKAAQAAGKE PVPSTSTSPP STPLSWEGIC LSRPLSLEDW DLSHPQGRAA YGGSHTDYIL
VPDLLQINNS PCYWGVLDRF QAEELLEGQP EGTFLLRDSA QDKFLFSVSF RRYSRSLHAR
IEQNGKRFSF DGRDPCMYRD PSVTGLLRHY SDPATCLFFE PLLSRPLTRT FPFTLQHLCR
AVICSCTTYQ GIKILPLPNQ LRDYLRQYHY KCNGACAV
//
