UniProt: A0A8U0Q3Z0

Database: UniProt
Entry: A0A8U0Q3Z0_SALNM

LinkDB:  A0A8U0Q3Z0_SALNM 
Original site:  A0A8U0Q3Z0_SALNM

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Ontology (10)   
   GO (10)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (21)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (2)   
   SMART (3)   
All databases (34)   

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ID   A0A8U0Q3Z0_SALNM        Unreviewed;       681 AA.
AC   A0A8U0Q3Z0;
DT   12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT   12-OCT-2022, sequence version 1.
DT   28-JAN-2026, entry version 17.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN   Name=LOC120033442 {ECO:0000313|RefSeq:XP_038835731.1};
OS   Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salvelinus.
OX   NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038835731.1};
RN   [1] {ECO:0000313|RefSeq:XP_038835731.1}
RP   IDENTIFICATION.
RC   TISSUE=White muscle {ECO:0000313|RefSeq:XP_038835731.1};
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Interacts with
CC       FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1. ITGAV:ITGB6
CC       interacts with TGFB1. {ECO:0000256|ARBA:ARBA00046864}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU000633}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR   RefSeq; XP_038835731.1; XM_038979803.1.
DR   AlphaFoldDB; A0A8U0Q3Z0; -.
DR   GeneID; 120033442; -.
DR   KEGG; snh:120033442; -.
DR   Proteomes; UP000808372; Chromosome 40.
DR   GO; GO:0009986; C:cell surface; IEA:TreeGrafter.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0034685; C:integrin alphav-beta6 complex; IEA:TreeGrafter.
DR   GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:TreeGrafter.
DR   GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:TreeGrafter.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:TreeGrafter.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   FunFam; 1.20.5.100:FF:000004; Integrin beta; 1.
DR   FunFam; 2.10.25.10:FF:000043; Integrin beta; 1.
DR   FunFam; 2.10.25.10:FF:000075; Integrin beta; 1.
DR   FunFam; 2.10.25.10:FF:000076; Integrin beta; 1.
DR   FunFam; 3.40.50.410:FF:000002; Integrin beta; 1.
DR   Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR040622; EGF_integrin_1.
DR   InterPro; IPR057073; EGF_integrin_2.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR057243; Integrin_I-EGF_CS.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR   PANTHER; PTHR10082:SF11; INTEGRIN BETA-6; 1.
DR   Pfam; PF07974; EGF_2; 2.
DR   Pfam; PF23105; EGF_integrin; 1.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF08725; Integrin_b_cyt; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01241; Integrin_b_cyt; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00243; I_EGF_1; 1.
DR   PROSITE; PS52047; I_EGF_2; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU000633};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000633};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        599..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..346
FT                   /note="Integrin beta subunit VWA"
FT                   /evidence="ECO:0000259|SMART:SM00187"
FT   DOMAIN          516..598
FT                   /note="Integrin beta subunit tail"
FT                   /evidence="ECO:0000259|SMART:SM01242"
FT   DOMAIN          622..668
FT                   /note="Integrin beta subunit cytoplasmic"
FT                   /evidence="ECO:0000259|SMART:SM01241"
SQ   SEQUENCE   681 AA;  74061 MW;  C085BB7CE894A881 CRC64;
     MALKLRTGSE VTFQISVQQT EDYPVDIYYL MDLSASMIDD LEMIKDLGST LSKEMAKLTS
     KFRLGFGSFV EKPVLPFIKI TPGELENPCR SVDESCLPTF GYKHVLPLTS STEKFNNIIT
     NQRVSANIDL PECGFDAIMQ AAVCGDKIGW RNDSMRLLVF VSDADSHFGM DSKMSGIVVP
     NDGECHLDSN NEYSMAAHLE YPTLGQLMDK LVDNNILLIF AVTENQKHNY ENYAHFIPGA
     TVGVLESDSR NILELIVTAY KELRSEIELE VLGDTEDLQI SFTAICQDGT VLPGQKRCSN
     VKAGDTVSFN VTVELSECLD GPQRFLIKPV GFQDPLEIDL ESLCSCACHQ TPEPNSSHCS
     LGRGSLECGS CLCDPGYMGS KCECTEESVQ SSNCKASGAP ESCSGQGECF CGQCVCHPSS
     FGRVYGAYCE CDDFSCVRFR GVLCGGHGDC DCGECVCQSG WAGEYCNCSS SRDKCVSEDG
     ALCSGRGKCV CGKCVCSMPG ASGDTCERCP TCGDSCSSAR TCVECHLQAE DEATEECVQR
     CSVPHVFVNN STEYDESRST LCTLMSENNC FISFSVVAGD IGSTVYNLKM YDCPEPPNIA
     MIVLGVSLSI LTIGLILLGV WKLLISVHDR NEVAKFEAER AKAKWQSGTN PLFRSSTSTF
     KNVTYKSAGG LKVDIHSMDG Y
//

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