ID A0A8U0THE2_SALNM Unreviewed; 2575 AA.
AC A0A8U0THE2;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE SubName: Full=Cullin-9-like {ECO:0000313|RefSeq:XP_038816080.1};
GN Name=LOC120017403 {ECO:0000313|RefSeq:XP_038816080.1};
OS Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salvelinus.
OX NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038816080.1};
RN [1] {ECO:0000313|RefSeq:XP_038816080.1}
RP IDENTIFICATION.
RC TISSUE=White muscle {ECO:0000313|RefSeq:XP_038816080.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330}.
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DR RefSeq; XP_038816080.1; XM_038960152.1.
DR GeneID; 120017403; -.
DR KEGG; snh:120017403; -.
DR Proteomes; UP000808372; Chromosome 22.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20347; BRcat_RBR_CUL9; 1.
DR CDD; cd20359; Rcat_RBR_CUL9; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 3.30.230.130; Cullin, Chain C, Domain 2; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR056405; ARM_CUL7_CUL9.
DR InterPro; IPR047561; BRcat_RBR_CUL9.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR055486; CUL7/CUL9_N.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047560; Rcat_RBR_CUL9.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22771:SF4; CULLIN 7-RELATED; 1.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF24742; ARM_CUL7_CUL9; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF23168; CUL7_CUL9_N; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1187..1366
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1608..1860
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT DOMAIN 2126..2344
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 2297..2340
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 55..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2502..2575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2416..2446
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 55..74
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..676
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..708
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2502..2517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2533..2565
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2566..2575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2575 AA; 289488 MW; 6FBD02704A06A848 CRC64;
MLGERRNGNL LVQLGPKLQA YPEELIRQRR THDGQTEYLI RWCLLTIDDG SCSGGGSNET
GGEGGSSSGV GGSTSGESKT ENILMWMSME DVYANCPTLL GKRKADAQRP LQEAEERPGG
DFPADVTFDE VELSDMKDDV KNLVRRARKQ MTKKSDFAIS TTHTIHVLSA YASIGSLVGV
FKETGALDLL MELLCNKEQQ TRRSAGKMLR ALASHDAGSR AYVLLSLSQQ DGIEQHMDFD
NRYTLLELFA ETTSSEEHGI SFEGIHLPQI PGKLLFSLVK RYLCVTSLMD KLNTAGVESS
SERQDAAGSS SGAGHQPENL RVQREFEFTM AMANLISELV HVMGWDHNRQ PPQSSSLAQG
RACGEDQEDV TPRRMLRSIF QPRFSASAFP VFTTSSMAAA TPPKKKTGSG FRTRTDFASR
SAYVEYVQDN LKSGMLVRML EDYEEVSAGD EGDFRYSNDG SPPVQVYWNS LSRTYWVHWH
MVEIMAAGTS GQGEKDAQEK ASSLTETIKL TAGKRGSPAP TESHLMSQTF FSKPPGGLYS
LPYLAEGLHA DGATLSRAEW WEVLFFIKKL EPKQQQEINN ILRQSLDEQM SDADEATLIR
LSVPGEVARK LLHYLKQTLQ NSCLWDLLCS HSFSKHYMRR GGGGLEDDEL LPDGCPGSSG
LGEGQGTSSS AGTASSFSVM GSFSKKPKKE SPTDYISDTE SELPMEESNY SEDLEEKMKV
FNNSKVQGKK TALEKLGEVV DIMKKSGSDP VQQLAGIKFI TKVLEDEGPQ ERSTLRTDAV
QTIRDKVLKL VVDMLSGQPK ENVVSTLRLT RTLMVKYEWR VSFATEGGVK AILSCMQEYP
TVPQIQQVAL ATLMVITGAS KYNLSSMSSC CLPLSESGTP MMLGVFASIG SATPEGSKGL
LAAIPAAIEL MLNTSGCMLS VRNGLLVIIM LISSSKNLAE QLVACDVSTV LKKCLAASRP
EKWLAIIALN HISMDHKLEK KELMEELDFK DAELKMLVVS LKEMTANKEV ILTLEQLLCD
NSSQLEEERN QVTRSRETYQ DLVRLMDQHR ADRATQLSIL RILNKVLDNY QEDLLPWHES
IEPCLSSMTT FINDREVVQQ LIRFLYRLAS LNKDYAVVMC RLGTKEALVK ALDKHSVNLL
MVTELRDLIT DCDKYASLYK KMTTSVLAGC IQMVLGQIEE HRRSHQPINI PFFDVFLHNL
CQGSSLELKE DKCWEKVEVS SNHHRANKLT DKNPKTYWES NGCTGSHFIN IYMHKGVAIR
QLAVLVASED SSYMPARIVV LGGDDPTNIN TELNTVNVPP SANRIVLLEN MTRLWSIVQI
RIKRCQQGGI DTRVHGFEVL GPKPTFWPVF KEQLCCRTYL FYTTKAHTWC QEILEDKAQL
LQLFNKLNSA LRHEQMFADR FLPDAEAAEA LGRTCWEALI TPIVQSITIS ETQVLSPLSW
LLTEYLDNAE SARRCKSRAA IFNSRVRRLT HLLVHVDTSR VNTEELKPPI KCKGINRSKV
LKNGKEGKNK DAAAVSSSSS NFVKPKGKNI SSIAGIALCW QGVVQRQVKK FLDSTCSQTD
FVERYRNMYL RLKNAMEELF GQQTAFVLAL RHGFSAALLQ LSILTAMHMS ERFAQYIDMM
IQKSGVDSGN VETLNQLQQF LEPMLFLSGL ELANTFEHCY RYYLGDRLLG QSKVWLETAV
IMQIGTCFPN RFPQQMLKNL SESEELQQEF HLYRLQQLDK TLQDVNEEMM DDQPSEPDEE
SEVKVLVLSP RCWAVSSPCY LDNSSRYFPK QLSTYLAEFT DFYSNSQCMY NLTHSKPRRL
QWTWLGHAEL HYGSCTLYVS TLQMYILLQF NHQQDVSVEA LQQATGLSPT VLAHALSPLT
AEKGILTTDS PDNNLVNGVL RLNKKALSQS LENRSYCYLL PKQTYLNVDE DAACSLERKR
NFIYCLIIQI MKAEKEMNID NLVFRVLDTC QKREVTRSPG SVRFSCSTTD VLSCVMHVIS
KGYIRRNEDS PHIVEFLPED PSTPQKGQAH FSFSKAELKN KPSSSNADIS LEGIIAAPQS
VEDGVLEAVL LSMGRTMNQE EVRQLMQRTV QQVSGTLSLD LDRAEHLLVH CKWNVDVLIQ
RYTDDPDSLV MAAGLRGWNP QPPPSPVSSC PVCLISQTGE AEPVPTLCCM HYCCRSCWQE
YLTARIEQNL VMNCNCPITD CRAQPTSQFF FNILTNKDTI AKYENALLRG YVECCSNLTW
CTNPLGCDQI LCRENIGSMG TCSKCCWSSC FSCNFPEAHY PASCSHMSQW IDDGGYYEGM
TMEAQSKHLA KLISKRCPSC QSQIEKNEGC LHMTCAKCNH GFCWRCLKPW KPTHKDYFNC
SAMVSKAARQ EKKFQDYNER CTFHNQAKDF AINLESKVSS INEALQMKSL TFVIDACKVL
AQARKVLAYS CVYSYYNQDT EKMDVMEQQM EALELHTNTL QILLEETLLQ CTDLASCIRL
LKPEHLNTGL ELIRRIQERL VAIIQHSTQD FRVGYNSKTG QELESAQASN LSKTTDANKV
AGGSESDNHN NEGGDEEDEW YDDEYVPEWH EDDEDDFFSD GDESENLERD FSPFD
//
