ID   A0A8U0TJ02_SALNM        Unreviewed;       549 AA.
AC   A0A8U0TJ02;
DT   12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT   12-OCT-2022, sequence version 1.
DT   28-JAN-2026, entry version 17.
DE   SubName: Full=Suppressor of cytokine signaling 5-like {ECO:0000313|RefSeq:XP_038817154.1};
GN   Name=LOC120018178 {ECO:0000313|RefSeq:XP_038817154.1};
OS   Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salvelinus.
OX   NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038817154.1};
RN   [1] {ECO:0000313|RefSeq:XP_038817154.1}
RP   IDENTIFICATION.
RC   TISSUE=White muscle {ECO:0000313|RefSeq:XP_038817154.1};
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_038817154.1; XM_038961226.1.
DR   AlphaFoldDB; A0A8U0TJ02; -.
DR   GeneID; 120018178; -.
DR   KEGG; snh:120018178; -.
DR   OrthoDB; 8820570at2759; -.
DR   Proteomes; UP000808372; Chromosome 23.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          397..492
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          487..536
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  60986 MW;  1300F806E20B6104 CRC64;
     MSEPKESGDR GKDRERGARP KVRQSRSEER RDAGGGQKAG RGKKGQTSRE QAGERPVSDG
     FEYGDLLTGL EPRDRCSSSP LKECRRWQGL EGVTSLSQDR GTARLAHGTA EPPISEAEGR
     GAGGSRTLRQ KIQDAMGQCF PIKTNTPSSS SSTQQVFMPQ AAAAAGAASS RRKIHLTELM
     LDDCPFAAGT ELAQKWYLIK QHTAPISTPP VVDTLVVSAS GSASNMAAVV EDVDDRLRER
     RRISIEQGVE PPPNAEIHTF EVTAQINPLY KLGPKLAHGM NELAGDDRAT IHQQQQLLLQ
     RQQQHQLLLQ SCLDTLDEVV AVASSSASAS ALVPVCEAAS VPDPMVDPEV TASLQPTRAA
     VPQAEGPPTQ DGYRIHTQID YIHCLVPDLL QITNLPCYWG VMDRYEAETL LEGKQEGTFL
     LRDSAQEDYL FSVSFRRYGR SLHARIEQWN HNFSFDVHDP SVFHAPTVTG LLEHYKDPNS
     CMFFEPLLSN PIHRTLPFSL QHVCRAVISS RTTYDGINVL PIPNTLKKHL KEYHYKQRVR
     VRRMDTWWE
//