ID A0A8U0TKV1_SALNM Unreviewed; 549 AA.
AC A0A8U0TKV1;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Uridine-cytidine kinase {ECO:0000256|RuleBase:RU003825};
DE EC=2.7.1.48 {ECO:0000256|RuleBase:RU003825};
GN Name=si:ch211-243j20.2 {ECO:0000313|RefSeq:XP_038819119.1};
OS Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salvelinus.
OX NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038819119.1};
RN [1] {ECO:0000313|RefSeq:XP_038819119.1}
RP IDENTIFICATION.
RC TISSUE=White muscle {ECO:0000313|RefSeq:XP_038819119.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: May contribute to UTP accumulation needed for blast
CC transformation and proliferation. {ECO:0000256|ARBA:ARBA00056790}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cytidine + ATP = CMP + ADP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00047436,
CC ECO:0000256|RuleBase:RU003825};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine + ATP = UMP + ADP + H(+); Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00048909,
CC ECO:0000256|RuleBase:RU003825};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3. {ECO:0000256|RuleBase:RU003825}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690,
CC ECO:0000256|RuleBase:RU003825}.
CC -!- SUBUNIT: Interacts with RNF19B. {ECO:0000256|ARBA:ARBA00065923}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the uridine kinase family.
CC {ECO:0000256|ARBA:ARBA00005408, ECO:0000256|RuleBase:RU003825}.
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DR RefSeq; XP_038819119.1; XM_038963191.1.
DR AlphaFoldDB; A0A8U0TKV1; -.
DR GeneID; 120019757; -.
DR KEGG; snh:120019757; -.
DR OrthoDB; 10257085at2759; -.
DR Proteomes; UP000808372; Chromosome 24.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008655; P:pyrimidine-containing compound salvage; IEA:UniProtKB-ARBA.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd02023; UMPK; 1.
DR FunFam; 3.40.50.2020:FF:000010; Uridine-cytidine kinase; 1.
DR FunFam; 3.40.50.300:FF:000200; Uridine-cytidine kinase; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR000836; PRTase_dom.
DR InterPro; IPR000764; Uridine_kinase-like.
DR NCBIfam; NF001097; PRK00129.1; 1.
DR NCBIfam; NF004018; PRK05480.1; 1.
DR NCBIfam; TIGR00235; udk; 1.
DR PANTHER; PTHR10285; URIDINE KINASE; 1.
DR Pfam; PF00485; PRK; 1.
DR Pfam; PF14681; UPRTase; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003825};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003825};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003825}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003825};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 107..294
FT /note="Phosphoribulokinase/uridine kinase"
FT /evidence="ECO:0000259|Pfam:PF00485"
FT DOMAIN 336..539
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF14681"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..50
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61972 MW; A16F765F1DB33FDA CRC64;
MAMKMNPNDV QMPQKEEGEK EEDRSMSRSD RSVQVKRKSS GSGDDSLGSL PKHPRCPLTP
SLSPRKRTTS QSKTEPPLLR TNKRTIYTAG RPPWYNVTGT TFKEAFVIGL CGGSASGKTT
VANKIIEALD VPWVVLLSMD SFYKVLTKDE QELAAKNEYN FDHPEAFDFE LLVTVLRKLK
KGKSIKVPVY DFTSHCRRKE WKTVYGANVV IFEGILAFAN KELLKLLDMK VFVDTDSDIR
LVRRLKRDIS DRGRDINGVI KQYNKFVKPS FEQYIEPTVQ VADIVVPRGG ENFVALDLIV
QHVHSQLEKR EITVRSALAS AHQGQPLPKT LSVLESTPQV RGMHTIIRNK DTNRDEFIFY
SKRLMRLLIE HALSFLPLKP VQVETPQGSI YEGKRLSGKR ITGVSILRAG ETMEQALMHV
CKDIRLGKIL IQTNHDTGEP ELHYLRLPKD ISEDYVILMD STVSTGAAAL MAVRVLLDHD
VQEDKIFLLS LLMAEMGVHS VAYAFPKVRI ITTAVDKKVN NEFHIIPGIG NFGDRYFGTD
TPSDWTESD
//
