ID A0A8U0UUK3_MUSPF Unreviewed; 673 AA.
AC A0A8U0UUK3;
DT 12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE SubName: Full=Forkhead box protein P4 isoform X3 {ECO:0000313|RefSeq:XP_044926951.1};
GN Name=FOXP4 {ECO:0000313|RefSeq:XP_044926951.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Proteomes:UP000000715, ECO:0000313|RefSeq:XP_044926951.1};
RN [1] {ECO:0000313|RefSeq:XP_044926951.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_044926951.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_044926951.1; XM_045071016.1.
DR AlphaFoldDB; A0A8U0UUK3; -.
DR GeneID; 101669952; -.
DR CTD; 116113; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20067; FH_FOXP4; 1.
DR FunFam; 1.20.5.340:FF:000005; Forkhead box P1, isoform CRA_f; 1.
DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047414; FH_FOXP4.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050998; FOXP.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF7; FORKHEAD BOX PROTEIN P4; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 460..533
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 460..533
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..50
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..673
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 72385 MW; 1C7B6FBE29471E3D CRC64;
MMVESASETI RSAPSGQNGV GGISGQADGG GGGGGGGGAG AAGAGGGGPG RDSAAGPDSN
GELSPAELLH FQQQQALQVA RQFLLQQASG LSSPGNNDSK QSASSVQVPV SVAMMSPQML
TPQQMQQILS PPQLQALLQQ QQALMLQQEY YKKQQEQLHL QLLTQQQAGK QQPKEALGNK
QLAFQQQLLQ MQQLQQQHLL NLQRQGLVSL QPGQASGPLQ TLPQAAVCPT DLPQLWKGEG
APGQPAEDSV KQEGLDLTGS ATTATSFAAP PKVSPSLSHH TLPNGQPTVL TPRRDSSSHE
ETPGSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ MQVVQQLEIQ
LAKESERLQA MMAHLHMRPS EPKPFNQPVT VSAADSFPDG LVHPPTSAAA PVTPLRPPGL
SSASLHSGGP ARRRSSDKFC SPISSELAQN HEFYKNADVR PPFTYASLIR QAILETPDRQ
LTLNEIYNWF TRMFAYFRRN TATWKNAVRH NLSLHKCFVR VENVKGAVWT VDEREYQKRR
PPKMTGSPTL VKNMISGLSY GALNASYQAA LAESSFPLLN SPGMLNPGSA SSLLPLSHED
VGAPVEPLPS NGSSSPPRLS PPQYSHQVQV KEEPQEAEED RRPGPPLGPP NPSTAAPPED
RDLEEELPGE ELS
//
