ID A0A8U1H076_SALNM Unreviewed; 648 AA.
AC A0A8U1H076;
DT 14-DEC-2022, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE SubName: Full=ETS-related transcription factor Elf-4-like {ECO:0000313|RefSeq:XP_038867947.1, ECO:0000313|RefSeq:XP_038867948.1};
GN Name=LOC120062216 {ECO:0000313|RefSeq:XP_038867947.1,
GN ECO:0000313|RefSeq:XP_038867948.1, ECO:0000313|RefSeq:XP_038867949.1};
OS Salvelinus namaycush (Lake trout) (Salmo namaycush).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salvelinus.
OX NCBI_TaxID=8040 {ECO:0000313|Proteomes:UP000808372, ECO:0000313|RefSeq:XP_038867948.1};
RN [1] {ECO:0000313|RefSeq:XP_038867947.1, ECO:0000313|RefSeq:XP_038867948.1}
RP IDENTIFICATION.
RC TISSUE=White muscle {ECO:0000313|RefSeq:XP_038867947.1,
RC ECO:0000313|RefSeq:XP_038867948.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_038867947.1; XM_039012019.1.
DR RefSeq; XP_038867948.1; XM_039012020.1.
DR RefSeq; XP_038867949.1; XM_039012021.1.
DR AlphaFoldDB; A0A8U1H076; -.
DR GeneID; 120062216; -.
DR KEGG; snh:120062216; -.
DR OrthoDB; 8196042at2759; -.
DR Proteomes; UP000808372; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR FunFam; 1.10.10.10:FF:000066; ETS-related transcription factor Elf-2 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849:SF191; ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B; 1.
DR PANTHER; PTHR11849; ETS; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004019};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000808372};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 200..282
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 148..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..174
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..324
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..337
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 70387 MW; BF610062772DB890 CRC64;
MATAVQPNEL VFEFASNGMD EINQLDDPSV FPAVIVEQVP AADLMQVYSG MESDEVANGI
MVDTTLHVVE EAIMVGDVGL SETTVSDTED SMETNEAAAA LLNMESPNNI LDEKRMIHTY
GTMLESDYTY IPLRPEANGC MDVSLDEETS SMDEIPQRSV SKPQRKTKVR KPRAVRPCSP
ITTPSLPFKK KSKEGKGNTI YLWEFLLALL QDKNTCPKYI KWTQREKGIF KLVDSKAVSK
LWGKHKNKPD MNYETMGRAL RYYYQRGILA KVEGQRLVYQ FKEMPLDLVV IDDEDTCPEL
SAGYGGQRPS HHGRGMGGRG GPRGGHGKNH AHGRHPISVK QVKREPIDMD GGLYHEVNGT
HAEQMNQTVH VLQPNQGAAV PASSHNSRNI NMATSVPMVL TSSGQLQPLL SNGDSSSHSS
PPRIILHTVP STTAGGKDVL TIQTASLATG AGSLQDHHHQ HQQPQFLVTS LGSTTGVINS
TTASLNGLPR LVTLNAATGQ PMVAQQPGTV IATVLKSSSG DELLHGLHGI KEEMLDPYYL
QSWVNGDPSF GMEAGEAELT YRTVIIGTNQ SLGQSQGETG SESPVNGHLA QGSSPSEGLT
PVEELEVRGE MALQPEHMLG VKGLQELPEI TLHLPSSFIQ IKTEPTEA
//
