ID A0A8V0XCM5_CHICK Unreviewed; 475 AA.
AC A0A8V0XCM5;
DT 14-DEC-2022, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=HtrA serine peptidase 1 {ECO:0000313|Ensembl:ENSGALP00010002216.1};
GN Name=HTRA1 {ECO:0000313|Ensembl:ENSGALP00010002216.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010002216.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010002216.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Broiler {ECO:0000313|Ensembl:ENSGALP00010002216.1};
RA Warren W., Formenti G., Fedrigo O., Haase B., Mountcastle J., Balacco J.,
RA Tracey A., Schneider V., Okimoto R., Cheng H., Hawken R., Howe K.,
RA Jarvis E.D.;
RT "Gallus gallus (Chicken) genome, bGalGal1, GRCg7b, maternal haplotype
RT autosomes + Z & W.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGALP00010002216.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010002216.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010002216.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010002216.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR RefSeq; XP_015144381.1; XM_015288895.4.
DR RefSeq; XP_040530839.1; XM_040674905.2.
DR AlphaFoldDB; A0A8V0XCM5; -.
DR SMR; A0A8V0XCM5; -.
DR FunCoup; A0A8V0XCM5; 26.
DR Ensembl; ENSGALT00010003912.1; ENSGALP00010002216.1; ENSGALG00010001705.1.
DR GeneID; 100857572; -.
DR KEGG; gga:100857572; -.
DR CTD; 5654; -.
DR GeneTree; ENSGT00940000156955; -.
DR OMA; PAECAGS; -.
DR OrthoDB; 4217619at2759; -.
DR Proteomes; UP000000539; Chromosome 6.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-ARBA.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0012501; P:programmed cell death; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd06785; cpPDZ_HtrA-like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.40.10.120:FF:000002; HtrA serine peptidase 3; 1.
DR FunFam; 3.30.60.30:FF:000026; Insulin-like growth factor-binding protein 7; 1.
DR FunFam; 2.30.42.10:FF:000142; Serine protease HTRA1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF13; SERINE PROTEASE HTRA1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00121; IB; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A8V0XCM5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..475
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036460444"
FT DOMAIN 24..108
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 104..152
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 360..461
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 475 AA; 50266 MW; 162EE4BB82DBB74E CRC64;
MLPPWCRSAL LLAVLPALLL AAPPPPACPE RCDRSRCPPL PSSCPGGPVL DACGCCRVCG
AEEGEPCGVG EGGPPCGEGL RCSVPPGGGV PASGTVRKRA AVGRCVCASS EPVCGSDAVT
YASPCQLRAA SRRAERLRQP PIIAIQRGGC GQGQEHPNSL RHKYNFIADV VEKIAPAVVH
IELFRKLPYS KREIPVASGS GFIVSEDGLI VTNAHVVTNK NRVKVELKNG ETYEAKIKDV
DEKADIALIK IDAQGKLPVL LLGQSGDLRP GEFVVAIGSP FSLQNTVTTG IVSTTQRGGK
ELGLRNSDMD YIQTDAIINY GNSGGPLVNL DGEVIGINTL KVTAGISFAI PSDKIKKFLT
ESHDRQAKGK AITKKKYIGI RMMSLTPSKA GELKDRHKDF PDVVSGAYVI DVIPETPAEA
GGLKDNDVII SINGQSITSA SDVSDIIKKD STLNMVVRRG NEDVMLTVIP EEIDP
//
