UniProt: A0A8V0ZWD2

Database: UniProt
Entry: A0A8V0ZWD2_CHICK

LinkDB:  A0A8V0ZWD2_CHICK 
Original site:  A0A8V0ZWD2_CHICK

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Ontology (3)   
   GO (3)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (6)   
   RefSeq(pep) (6)   
Protein domain (7)   
   InterPro (4)   
   Pfam (2)   
   SMART (1)   
All databases (20)   

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ID   A0A8V0ZWD2_CHICK        Unreviewed;       320 AA.
AC   A0A8V0ZWD2;
DT   14-DEC-2022, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 1.
DT   28-JAN-2026, entry version 17.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   Name=BBS5 {ECO:0000313|Ensembl:ENSGALP00010035174.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010035174.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010035174.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Broiler {ECO:0000313|Ensembl:ENSGALP00010035174.1};
RA   Warren W., Formenti G., Fedrigo O., Haase B., Mountcastle J., Balacco J.,
RA   Tracey A., Schneider V., Okimoto R., Cheng H., Hawken R., Howe K.,
RA   Jarvis E.D.;
RT   "Gallus gallus (Chicken) genome, bGalGal1, GRCg7b, maternal haplotype
RT   autosomes + Z & W.";
RL   Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGALP00010035174.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010035174.1};
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSGALP00010035174.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010035174.1};
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
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DR   RefSeq; XP_025007961.2; XM_025152193.3.
DR   RefSeq; XP_046777347.1; XM_046921391.1.
DR   RefSeq; XP_046777348.1; XM_046921392.1.
DR   RefSeq; XP_046777350.1; XM_046921394.1.
DR   RefSeq; XP_046799554.1; XM_046943598.1.
DR   RefSeq; XP_046799555.1; XM_046943599.1.
DR   AlphaFoldDB; A0A8V0ZWD2; -.
DR   SMR; A0A8V0ZWD2; -.
DR   Ensembl; ENSGALT00010057985.1; ENSGALP00010035174.1; ENSGALG00010023762.1.
DR   GeneID; 424165; -.
DR   CTD; 129880; -.
DR   GeneTree; ENSGT00940000158859; -.
DR   OMA; PNFGIQY; -.
DR   OrthoDB; 10261999at2759; -.
DR   Proteomes; UP000000539; Chromosome 7.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd00900; PH-like; 1.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT   DOMAIN          7..61
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          137..191
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   320 AA;  36475 MW;  F1811E9F0F20EE57 CRC64;
     MKMRPGEVLI DCLESIEDTK GNNGDRGRLL VTNLRIIWRS LSLPRVNLSV GYNCIINITT
     RTANSKLRGQ TEALYILTKC NNTRFEFIFT NVVPGSPRLF TSVIAVHRAY ETSKMYRDLK
     LRSALIQNKQ LRLLPQEQIY DKINGVWNLS SDQGNLGTFF ITNVRIVWHA NMNDSFNVSI
     PYLQIRSIKV RDSKFGLALV IESSQQSGGY VLGFKIDPVE KLQEAVKEIN SLHKVYSANP
     IFGVDYEMEE KPQSLEDLTV EQVQDDVEIE PGEQTDAFVA YFADENKQHD REPVFSEELG
     LAVEKLKDGF TLQGLWEVMT
//

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