ID A0A8X6WDV2_TRICX Unreviewed; 1412 AA.
AC A0A8X6WDV2;
DT 14-DEC-2022, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=YTHDC2 {ECO:0000313|EMBL:GFY33088.1};
GN ORFNames=TNCV_2230371 {ECO:0000313|EMBL:GFY33088.1};
OS Trichonephila clavipes (Golden silk orbweaver) (Nephila clavipes).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Araneoidea; Nephilidae; Trichonephila.
OX NCBI_TaxID=2585209 {ECO:0000313|EMBL:GFY33088.1, ECO:0000313|Proteomes:UP000887159};
RN [1] {ECO:0000313|EMBL:GFY33088.1}
RP NUCLEOTIDE SEQUENCE.
RA Kono N., Nakamura H., Mori M., Yoshida Y., Ohtoshi R., Malay A.D.,
RA Moran D.A.P., Tomita M., Numata K., Arakawa K.;
RT "Multicomponent nature underlies the extraordinary mechanical properties of
RT spider dragline silk.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GFY33088.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BMAU01021407; GFY33088.1; -; Genomic_DNA.
DR Proteomes; UP000887159; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProtKB-ARBA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR FunFam; 1.20.120.1080:FF:000008; probable ATP-dependent RNA helicase YTHDC2; 1.
DR FunFam; 3.10.20.370:FF:000001; Retrovirus-related Pol polyprotein from transposon 17.6-like protein; 1.
DR FunFam; 3.30.70.270:FF:000020; Transposon Tf2-6 polyprotein-like Protein; 1.
DR FunFam; 3.30.70.270:FF:000003; Transposon Ty3-G Gag-Pol polyprotein; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050951; Retrovirus_Pol_polyprotein.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR059023; RNA_hel_CTD.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR PANTHER; PTHR37984:SF5; PROTEIN NYNRIN-LIKE; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF26026; RNA_hel_CTD; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:GFY33088.1};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:GFY33088.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:GFY33088.1};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000887159};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022695}.
FT DOMAIN 1..80
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 420..536
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 550..726
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1223..1353
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
SQ SEQUENCE 1412 AA; 160555 MW; 64D57061EE3D922E CRC64;
MSFGLRNAPS TFQRFITEVL YGLDFVFPYL DDVLVASSTE EEHSEHLKMV FERFQQYGLR
INVSKSVMGA AQVEYLGFLI TAEGSRPLPE KVQAIFNYKL PETIHDLRTF LGMINFYRRY
LKDAAKTQAP LHELLKGAKK KDSRKVHWTD DTRRSFEKCK TDLAEAALLS FPRSGLPLSL
CTDASDFAVG AVLQQLENER WKPIAFYSKK LNETQTRYST YDRELLGIYL SVKHFKHLLE
GNDFVIYTDH KPLTFAFKQK NEKASPRQQR QHQYISEFSC NIQHVLGKDN VVADALSRIH
SISEINFEEI AEEQTTDEEL QILLHNNSLK FKPSTLPSGK KLWCDISTQK IRPYIPQKFR
FQIFQLIHGL AHPGIKSTVK LMIEKYVWSD IKKQVREWAK ACIRCQKCKV SRHTKSKLGD
FEQPDERFSV VHIDLIGKLP PSEGMQYCLT CIDRFSCWME AIPIPEITAE IVGRAFYEKW
ICRFGVPAKI VTDQGRQFEA ELFRSIAAIC GAKVAHTTSY HPQCNGKVER LHRTLKGAIK
AHNNIRWTES LPTVLLGLRA AIRPDISYTI AQMVYDRLKP AYLLAVDNQN EQTSVGQKNE
ISNWKELSPM PDEQSTTSCG RKIKKPILST NIAETSVTIN DVVFVIDCGK VKEKSYDSLT
GVTHLKAGWI SKASAIQRRG RAGRCRPGLC YHLYSRARFN SFQKFQVAEI LRVPIHELCL
QAKLLAPPNA PIADFLAKAP DPPPFMVTRN AVTLLKTIDA LDPWEELTEL GLHLLDMPIE
PRLGKMILYS VVLKCVDPIL TIVCCLSYRD PFLIPSQPAQ KRAVAMAKRK FACDTFSDHM
VLLRAFQAWQ KAKVEGHERI FCARNFISHA TMEMVVAMRS QLLGQLRASG FIRARGNSDI
RDLNTNSEIW AVIKAALCAG TYPNLIRIDR DRQQLITQKE SKVRFHHSSV LNKLPVNAKH
SVAALRKQMI QELPCDWLVY EEMMRTGSIA HAHCCSLITP ITVSLFAGPA RLPLDALHEP
DQARLEGYME EGDSEDDTKY DNQKAMFKID DWISFRVEPE IARLALQLRQ KWHALFLKRM
HAPSKVLTPA DECVIRTIAN VLIVEDQFLN LVQPTGIGQR PRPILGEYTS PVHLRKPMPT
SPSHRNPNYF NPNTSFNTSG LSCYSDEMPM MSNTVGSSSN YNPAFSSCSP QRNPMSSPFN
TSSLLQMASK QEFTPPCVTN SRIRYFIIKA NTSRVVEVSM AKNIWAFTST TERKLLSAIK
EGKEVILIFS IQGSGHFQGF ARFTPHLSDQ RPPEFSAANL GTCYQIEWIK KANIPFQSTR
HLQNAWNENR KVQISRDGQE LEPSVGESLC KLIVKGQPVF TSECFKSTRR PLPFIGDTSA
LNRGQMQWDQ SPSSSWYDAG PVGQKYWSQS NT
//
