ID A0A8X7XJR9_POLSE Unreviewed; 553 AA.
AC A0A8X7XJR9;
DT 14-DEC-2022, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:KAG2467372.1};
DE Flags: Fragment;
GN Name=Socs5 {ECO:0000313|EMBL:KAG2467372.1};
GN ORFNames=GTO96_0010261 {ECO:0000313|EMBL:KAG2467372.1};
OS Polypterus senegalus (Senegal bichir).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX NCBI_TaxID=55291 {ECO:0000313|EMBL:KAG2467372.1, ECO:0000313|Proteomes:UP000886611};
RN [1] {ECO:0000313|EMBL:KAG2467372.1, ECO:0000313|Proteomes:UP000886611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bchr_013 {ECO:0000313|EMBL:KAG2467372.1};
RX PubMed=33545088;
RA Bi X., Wang K., Yang L., Pan H., Jiang H., Wei Q., Fang M., Yu H., Zhu C.,
RA Cai Y., He Y., Gan X., Zeng H., Yu D., Zhu Y., Jiang H., Qiu Q., Yang H.,
RA Zhang Y.E., Wang W., Zhu M., He S., Zhang G.;
RT "Tracing the genetic footprints of vertebrate landing in non-teleost ray-
RT finned fishes.";
RL Cell 0:0-0(2021).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG2467372.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAATIS010000859; KAG2467372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A8X7XJR9; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP000886611; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000886611};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAG2467372.1"
FT NON_TER 553
FT /evidence="ECO:0000313|EMBL:KAG2467372.1"
SQ SEQUENCE 553 AA; 63060 MW; B2E035280F7F736D CRC64;
MDKMGKMWNN LKNRCHNLFH SENTSKNENS LDVNFIGCSL EQPNSICLSE LPSQATASTH
QRLCPLPLVS DNLQNVPRRN QNCVSDIPQI MEITIDKDFE DLRAAASTRL ARRDSYSRHA
PWGSKKKHSC STKTQSSLET DKHFSRTRNG LQRRERRLGV SSVHDMDSTS TRTLNVCSFR
QRLQDTVGLC FPIRSRSRSS KVTFSAKRKI HLSELLLEKC PFPAGSDLAQ KWHLIKQHTA
PVSPQSATLL DAFASTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QINPLYKLGP
KLPPGIGDIT GDSRSSAIVN SVPVGSVTAG PQQAAPLLTD FDSEEDATTL CLQSRRPKQR
HTSGESHYCR QGPWKVHTQI DFIHCLVPDL LQITSNPCYW GVMDRYEAEA LLEGKPEGTF
LLRDSAQEDY LFSVSFRRYN RSLHARIEQW NHNFSFDAHD PCIFHSSTVS GLLEHYKDPS
SCMFFEPLLT MPLHRTFPFS LQYICRAVIC RRTTYDGIGL LPLPAALQDF LKEYHYKQKV
RVRWLEREPI KVK
//
