ID A0A903V8B8_AEDAE Unreviewed; 1953 AA.
AC A0A903V8B8;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 02-APR-2025, entry version 9.
DE RecName: Full=CAP-Gly domain-containing protein {ECO:0000259|PROSITE:PS50245};
GN Name=5579471 {ECO:0000313|EnsemblMetazoa:AAEL019852-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL019852-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL019852-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019852-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL019852-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019852-PA};
RG EnsemblMetazoa;
RL Submitted (OCT-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EnsemblMetazoa; AAEL019852-RA; AAEL019852-PA; AAEL019852.
DR OrthoDB; 2130750at2759; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005938; C:cell cortex; IEA:TreeGrafter.
DR GO; GO:0035371; C:microtubule plus-end; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:TreeGrafter.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 2.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR032108; CLIP1_ZNF.
DR PANTHER; PTHR18916:SF82; CAP-GLY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR Pfam; PF01302; CAP_GLY; 2.
DR Pfam; PF16641; CLIP1_ZNF; 2.
DR SMART; SM01052; CAP_GLY; 2.
DR SUPFAM; SSF74924; Cap-Gly domain; 2.
DR PROSITE; PS00845; CAP_GLY_1; 2.
DR PROSITE; PS50245; CAP_GLY_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 235..277
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT DOMAIN 364..406
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1901..1928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 474..533
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 584..646
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1578..1735
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..27
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..91
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..128
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1953 AA; 218705 MW; FFD849DA46501EAF CRC64;
MSDTTNGAAS APPNGAAEPA SSSEKPSTNG STDQPPAKPA SGIPAPGSKI GVRSIPKPSG
IKPPTLSSMS HSSSTTSLAS TSSTAPLGTT SRIGRPCMGH HAPKAGPPPP ESKNDSSSDT
ASSSLSISRM RRPSDTDYSK SHLPDVDEES ETDLVYERTS RSSRSPDSGF RSNRTSQDRK
ISSTSATGSD LYWEATGRRR SSDQGVVLTT DTDSFIIGQR VWVGGLRPGH IAYIGETHFA
PGDWAGVVLD EPNGKNDGSV SGKRYFQCEP KKGVFSRLTR LTRDPLPGAA TAGGSSSAGD
TSMDQSLRSL TSPARSGAVS PTHSVSSFIS KSPAAGKAAT LTVGDRVIVS SGFGSRPGIL
KYLGETQFAS GTWCGVQLDE ASGKNDGSVD GVKYFDCPDK YGIFVPIAKV TLSPSSRKAR
LSRSGSKESL TSVGTMSSIA TTATSRLRMS AQRKSSVSAV PSTPKSSFSL QDVLREKQNH
IEQLMREREI DREENANQTI MYQKSVQQLK EKLAKLETQL AEEKRRNEDL QFSVDEVTFC
GEELNRKIQN SVHAQTQIFK ERIADLEKKL GEKGSSQAEP DLPAKDTVDA SSQLNLEIDK
LKAEILQRDQ KLHLSEELKH SLENEISKLH ERVAEAEKNL DFKESSFNIS EQCLKEKIAY
LEDRIEVLGV ELTAKDAELE KQYLDLKNAE GQLDEEVSHL QSDLRAKESL VVEKERQIEK
LTGEIQGLLN DIRQRDVKLL EGESGLKAVL EEKDGAIGKL KKELEELRVK EESAKVAVED
RGRKLGELNV RIVSNEEIIK KLEDSLKDAK KVEQTLEEAI KAKEKSLEEK ESLLAKIQDD
LKNSSAGSEQ QMVLLRSKET ELEQKQHEVE AKQFQISNLE STVTDLTKKL EEAVKDREAR
LAEQRASLEF ETKSKEDLLN KLANYETEQL AKDKLLEDND VLISSLQTKL KDLEVAKASV
VQELEDTTKR FADRDSALGK LNEERMHLSE QLEKTRKESA SAIALLEERL KNAQKLHEED
VRKAKEAQKD TLASKDAIVS ELEASLDKLR QEKTELLLQL NQSGATQKTT SDELTSKLNE
NRELNKQIES LTAQLATKTE NLDKLNQSLT GTNGKLEATE AKLIELQEAF GKLEIEYADL
KRKLEAQEQK STQLQQQKQD LEKEIDTLRS STLDSNSELS KVTDELKTKQ KQLEELQDAF
NGSKIDMERR LDEANQTNQG LNEQIDRVRN EMQQVSSQKI DRENELNVEL AKIKETAEIE
RENLVQEIAG LKASFEEERN QLVKGGVAKS EEFETVKEEL SGKVKSLEKS LSELERELAK
NRECAVKERE EAEGRLKEQM EKETTLQKEF DELKKEESSL RAALEDLRQS MEKGSHDASS
QLDAKNTKIS ELEKELRSVQ EELSRKQEQV DDSTKQLERN AETHSDLLKQ LEQNLNQIQE
LSGDKAKAEG SLKEISDELA SFKAKYDEME EEQVDLVSRK EGLKAEVKQL RDALENAEKE
KGEFGLQLEM VKGGSAKIEE ELQESKSKFE VEIAHLNGLI EEKSKAIDEF KARVEELMPL
VKLTEELKQE LTAKGTYIEQ HKEEAQKQLN EIERLHKEVK EKESYVFEKD SSVAELRKKL
EQKQEETQQL MKKLEYTEKC LTEKSQQEEK TAATSSELKE ALEKSKAAVK EQDDKIKEQG
RTINELETKL SAQSTQFEEL LNKKKASETE SSHKLHEMNQ KLLELENVKQ QEISDLSAKL
AETMNRFETQ MAESAKTVGS MRSVEKRQYE LECEKKEMEL RETEMQITTR KLQKEVDLLR
SQLLLKDSEV RKLTQELANA PTSAPLISSA EANGDTEAQI SFLNSIIADM QRKNDKLTLR
IQALEQTSIE GPNTSFEFSK RKPAPRVFCD ICDEFDLHET EDCPKQCSDS PPESLKHPSA
EPRERKIPPP RKYCEGCEVF GHELGECPDD ETY
//
