ID A0A913YF32_EXADI Unreviewed; 3958 AA.
AC A0A913YF32;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Transformation/transcription domain-associated protein {ECO:0008006|Google:ProtNLM};
OS Exaiptasia diaphana (Tropical sea anemone) (Aiptasia pulchella).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Aiptasiidae; Exaiptasia.
OX NCBI_TaxID=2652724 {ECO:0000313|EnsemblMetazoa:XP_028513608.1, ECO:0000313|Proteomes:UP000887567};
RN [1] {ECO:0000313|EnsemblMetazoa:XP_028513608.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR RefSeq; XP_028513608.1; XM_028657807.1.
DR EnsemblMetazoa; XM_028657807.1; XP_028513608.1; LOC110234904.
DR GeneID; 110234904; -.
DR KEGG; epa:110234904; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 5570127at2759; -.
DR Proteomes; UP000887567; Unplaced.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0000124; C:SAGA complex; IEA:TreeGrafter.
DR GO; GO:0006281; P:DNA repair; IEA:TreeGrafter.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:TreeGrafter.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000887567}.
FT DOMAIN 2701..3277
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3600..3922
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3926..3958
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 191..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3292..3338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3353..3388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..545
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3338
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3353..3366
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3374..3383
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3958 AA; 447216 MW; 841F30ABF3F05D1A CRC64;
MATANAIPAQ HSTSEGIIKK CTTYSNLLTE SSVADENKLK AAQEISENFE TIXQSSSYPS
FLEHAIPKFI QFLRDGEPQF VAESTLQQIR KLLLEILHRI PTNEHLRTHY KSILSLMFLL
LEVENEENVL VCLRVIIELH KQFRPPLQPE IQHFLQYVKT IYKELPVNVK QIFEVVSISA
TGYLPSENQG SALSNASSQG TTPVGTPAAS PMSTGDGAGG KSAQQTTIPK AINSLKVLAE
LPIIVVLMYQ LYKQNVYNVV ADFIPLVMST IVLQPSLNAR KSPSFNKEVY VDFVAAQIKT
LSFLAYIIRI YQEMVNTYSQ NMVGGLLGLL RYCPQEVAHL RKELLIAARH ILATDLRNRF
VPHIDQLFDE EVLIGTGWTT RESLRPLAYS TLADLVHHVR SHLPLPHLSL AVNMFSKNVH
DDSLPVSIQT MSCKLLLNLV ECIRQKSDEQ GSGREILMRM LEVFVRKFQS IAKHHIPAIF
DKCQQASESS TASSSSSPSQ NIGTANTTTT TATTTTASTA SSTSTTVSTA TTGSLLSSSS
TASTSEAPQT DQEIINKKPX SSSPSVAPFN IFSVPDCRSM VKTLVCGVKT ITWGAGSCKV
PGGNKTFLPW ETQLFTRLLK YALQALDIYQ VSVTPNGQYF LRPPSSQQVR MKEEKEILEH
FAGVFTMMNT SVFKEVFSSS IEYLVERIHT NYALQIIPNS FLANPNTSAT FATILVKFLL
ERLDEMGTNV DCSNLYLKLF KLVFGSVSLF ASENEQMLKP HLHEIVNRSM ELSCTSKEPY
NYFLLLRALF RSIGGGSHDL LYQEFLPLLP NLLQGLNNLQ SGVHRQYMKD LFVELCLTVP
VRLSSLLPYL PMLMDPLVSA LNGSQTLVSQ GLRTLELCVD NLQPDFLYDH IQPVRAELFQ
ALWKTLRNSN DNIAHVAFRV LGKFGGGNRR MLKEPQKLTF NDADTLGSCL AIYYPESVNP
VTISVGPVIE RALTFLKTLP PNVTVLPQQS SINLDHTIFY RKQAWIVVKS YLAAMISLED
NDAILTQVLG HKSFKEGQPP VVNKTATVPC GDLPSKNIIE QALTGVLLSA SIKELRSEAV
PFMCSLVRHF TLVGIVQQAG PCPVKPQNRS HRGMDIHIIV DAITAVMGME DKEFCKVGEL
AVAIMIETAT AVMDNAYKAA QLPLFEYLSE KLIGCCYERA WFTKSGGCTA ICFLMKRMPL
RWLIEHQLSF INALFFVMMD LTNEVSAGTL DSAKELLMNL IRQCNTPVQE SENEEIKAVQ
LKIFPTLSQH LIREIVSPNE TVRKQAQLSI NVLAEISGKT VYDIMAPHKG ILEDMIPPKK
HLLRHQPVNT QIALMDGNTF CTTLNPRLFS MDLSIVEHKV FFTELLSLCD ADDAHLLKLP
CYKSVQSLTP LRKSALHALS VCNYIVQARE KTFTVLYKAL NSPVEDIQET AKECLKKFMS
GPQIDMELVH MSIRPLLLML GDYRNLNLPL MQRLSHLMEL FPGSFNEKLC EQLLAHLKKW
ADVIITVTTQ AQQTSGAKIP RKAEEDLKIC EAIINMFHLI PAASSKLIDH LIQLVLKIEK
VLMIEVGSPL RAPLLKFLIR YPSQTCDYFL LHIAESQMNR LLMHYLKLKD DAKTLRTTLE
SYSLMLVNSL FNIPQPPDDQ VSAIQKKMEL QYQGILIIRL LVKFNDNWLP EHPVIIGHLR
RVWISKSFQD RLNKDGTPVH RWREPKLLVK CLLNYIKHRP GEVELLFQLL RVFTMRHVPD
FHFLRKFLDD TVAKGYSIEQ KRHVFFQFVK LFEDQYFPQE LKAKALQYVL IPMFQVSLER
GEGDNLIGGP PNPEHDSSEN VISVFVSKVI NPDNPFGTSD AVRILLLQFS ALLVEHASQY
IHDVANKKQG TKLRRLMTFA WPCLLPKQCV DPSTKYHGHL LLAHIIAKFA IHKRIVLQVF
HSLLKAHAVE ARGVVRQALD ILTPAMPARM EDGNTMLTHW TKKIIVEEGH TVAQLVHMLQ
LLVRHYRVYY PVRVYLIQHM VSAMQKLGFT ANAIIEHRKL AVDLAEVIIK WELQRIKDEQ
EQSNESEQQT TLQGSLKRPA DESTATSHDT KRTRSLSQTA ASSRVAVAIQ ESKLKSPLEK
HHSDALVNFL LRIACQVNEP STAVGSQGES LSRRCVLLLK TTLKPDLWPG ADLRVAWLDK
LLVTVEQTPA ANYANVCTAI EILTYLLSVL PQQTILTLFK PLQRGIATCM TCQNTKVIRA
IHTLLGRLMT LFPLDPTATK YEELEGLYNN IGKVICDGLT NFERATNAAT SILYGPLMIL
KAACVHNPSY IDNLMNPFMR ALQRMHKDHI NAVLGESTGA SEMLILCLEL IKNRIGVMTA
EIRKHFFTIV VTLIEKSPDS KLLRAITKIV EEWIKTKVTQ LTIQHLPTLR EKTVLLYRMM
INYEKRFPDD FELQAQFLEL VNFVYRDETL LITELASKLE PAFLSGLRCV QPQIRSRFME
VFDKTMKKKL YDRLVYIFCS QNWEAMGAHF WIKQCIELLL AVSDCERPIT PSSTFSXLPS
MTSFIRSDDS PLAKEILSKA TSNINESKLQ ESMETDEKKE ETEKEKENIF LFGESDANKL
FELMEKRNKV ENSQHVIQNL VAIHTKFLEE LHNVKSASFL GAMAQLCHST SKLAHKIWVH
LFPQLWSILS DRQQQVLAGE LSPFMCSGSH LVQVDVHPSA VHSILEGVSK CDPAIPIRPC
ILKYLGKTHN SWHRSALTLE EYALLCDEFT NPHITQQQSL DYTLYDEDAT EINPNETLDS
LAEMYSLLNE EDMWASLWQQ RXRNPETATG IAYETQGFFE QAQTVYEMAM NKARDEHNKA
PASPAVLSEY KLWETHWLRC AKELGQWDLL MEFGKSKSHP NPVLVLESSW RVPDWQAMKD
ALSQVELNFP ENIAYKLSLY RGFVAICHPD EPHLNMVDKL VEHSTSQSIR QWRRLPPIIS
HQHLPLLQAA QQIIELQEAA QIHIGLQPNS VGRSASLHDM KAIVKTWRNR LPMPSDKLSH
WSDIFMWRHH HYQAIVAAYD GQSSHEQQSN HAMLGVHASA WAIIHYGYIA RKQNLTGVCL
DSLSRIHTIP SVPIVDCFQK IRQQVKCYLQ MAGSMGKTEL QEGLEVIEST NLKYFTKEMT
AEFFALKGMF LAHIGRSEDA NKAFSQAVQM HDSLVKAWAL WGDYLDNLFT RERNMQLGVS
AIVCYLHACR HQNEAKCRKY LARTIWLMTY DDEKGSIADA VDKYCVGVPP VHWLPWIPQL
FTCLVRREGQ KILNLLGNIG RVYPQAMYFP IRTLYLTWKI EQRERHKVEA AAAXNRTMSQ
STSASVASPX SANDNKTPSS SDTGTKGTST TITTSQATST GVISSSSVMA KSLTTSSSTP
ISTGGSSEHG GNPSTSSNSS SQSDTGTIRA TAQMWRCSKI MHMLRDLHPT LLSALEGIVD
QMVWFRECWH EEVLRQLRQG LTKCYQVAFE TRGDVSNARI TPHTLSFVKK LVSTFGIGFE
PASSVSTTLS TAASESLARR AQATAQDPVF QRLKEQFATD FDFSVPGAMG LHNLIGKLKK
WIKILEEKAK LLPSSFLLED RCRFLSNFTT STAEVELPGE FLMPKANTHS PYYIRIARFM
PRVELVQKHN FSARRLFIRG NNGKVYPYLV VNDACMTESR REERILQLLR LLNLYFEKRK
ESCKRNLLFT VPKVVAVSPQ MRLIEDSPSL ISLREILSKR CGRKHLQSDS PIALYYDRLA
AVQSRGLQVT HQVLRDILRE IQGTMVPEYM VKEWAQYTYA DPTDYWTFRK QFCVQLTLLG
FAEFTLHLTR LGPEMLQVAQ DSGRLTVTYF RFEIDDSKGE LDANRPVPFR LTPNIAEFVT
PVGVNGVMTS AMVAAARCLV EPQFSIQSIL RAVIRDEMIT WHKKKQDDTH PLAVVSSPSD
MDSELLITLV NGAVNAITTR LQNLAQYEGG ETKVSTLIQA ATSADNLCRM DPAWHPWL
//
