ID   A0A914EKH0_9BILA        Unreviewed;       938 AA.
AC   A0A914EKH0;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   05-FEB-2025, entry version 10.
DE   RecName: Full=Pre-mRNA-processing factor 6 {ECO:0000256|ARBA:ARBA00020235};
DE   AltName: Full=PRP6 homolog {ECO:0000256|ARBA:ARBA00032140};
DE   AltName: Full=U5 snRNP-associated 102 kDa protein {ECO:0000256|ARBA:ARBA00031070};
OS   Acrobeloides nanus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Cephalobomorpha; Cephaloboidea; Cephalobidae; Acrobeloides.
OX   NCBI_TaxID=290746 {ECO:0000313|Proteomes:UP000887540, ECO:0000313|WBParaSite:ACRNAN_scaffold8384.g26093.t1};
RN   [1] {ECO:0000313|WBParaSite:ACRNAN_scaffold8384.g26093.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex, one of the building blocks of the spliceosome.
CC       Enhances dihydrotestosterone-induced transactivation activity of AR, as
CC       well as dexamethasone-induced transactivation activity of NR3C1, but
CC       does not affect estrogen-induced transactivation.
CC       {ECO:0000256|ARBA:ARBA00046247}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   WBParaSite; ACRNAN_scaffold8384.g26093.t1; ACRNAN_scaffold8384.g26093.t1; ACRNAN_scaffold8384.g26093.
DR   Proteomes; UP000887540; Unplaced.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:TreeGrafter.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:TreeGrafter.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:TreeGrafter.
DR   FunFam; 1.25.40.10:FF:000058; Pre-mRNA processing factor 6; 1.
DR   FunFam; 1.25.40.10:FF:000429; Pre-mRNA-processing factor 6, putative; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR010491; PRP1_N.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR   PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR   Pfam; PF06424; PRP1_N; 1.
DR   Pfam; PF13428; TPR_14; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   SMART; SM00386; HAT; 13.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000887540};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          3..154
FT                   /note="PRP1 splicing factor N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06424"
FT   REPEAT          706..739
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..67
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   938 AA;  107607 MW;  08CFF982B05BC391 CRC64;
     MPAPSGYVAG VGRGATGFTT RSDIGPARDS TDIPMEAALA APAPKKARDD DDEEAEDLND
     ANYDEEFGYS GSLFAKDPYD KDDEEADAIY HAVDMRQDEK RKDYRERKYR EAVEKYRQER
     PKIQQQFSDL KRQLAEVTED EWAAIPEVGD ARNKSKRNPR AERFTPVPDS VLSMGMQYGQ
     MNSVLDRNIQ SGLTTPYSGF QSTLGGMTST LGGMASGILT PGWKTGIQTG TSTDLDLRKI
     GQARNRIMDI RLNQVSDSVA GQTVVDPKGY LTDLQSMIPK YGGDINDIKK ARQLFKSIRE
     TNPKHPPAWI ASAKLEEVVG KIQAARNLIM EGCDKNPKSE DLWLEAIQLH PPDVAKSIVA
     TAVQHLPNSV RIWMKAADIE TDKKAKRKVL RKALENIPHS VRLWKAAVDL EEPEDARQLL
     TRAVECCSSS TELWLALAKL ETYDNARKVL NKARENIPTD RLIWIAAARL EESRGESNMV
     DKLIDRALLS LKANKVEINR KHWLEDAIDA ERASCRLTAQ AIIKHVMGVG VEEEDRKHTW
     MEDAEWFVTE KAYECARSIY AFTLNTFPKK KGIWTCAAFF EKDHGTVEGY EQLLEKATEN
     CPQAEKLWLM YAKSKWIHGN VEAAREILSR AFQHNPNSEG IWMAAVKLES ENNEYQRARK
     LLQKARNLAP SPRIWMKSAR LEWCLNELEK AKGLLREGIE KYRDYEKLYM MMGQILTQER
     NYEEARKVYN EGVRRCPNSI PLWLLIVRFE ESQNRSTKAR SDLDVARIKN PKNERLWLEA
     IRIELRAEQR ELAESLLARA LQECEHSGIL WSEAIFLEQR HGRKTKSVDA LKRCEHDPHV
     LLAVAKMLWA ERKIKVAREW FQKTIKVNPD FGDAWAYFYK FEMIHGNEEE RAEVKKRCIQ
     AEPRHGELWQ EISKDVKNWR LQIEEILELL TARLEIPK
//