ID   A0A914FBY9_9BILA        Unreviewed;       673 AA.
AC   A0A914FBY9;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   18-JUN-2025, entry version 10.
DE   RecName: Full=Urocanate hydratase {ECO:0000256|ARBA:ARBA00070010};
DE            EC=4.2.1.49 {ECO:0000256|ARBA:ARBA00011992};
DE   AltName: Full=Imidazolonepropionate hydrolase {ECO:0000256|ARBA:ARBA00031640};
OS   Panagrolaimus sp. ES5.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Panagrolaimoidea; Panagrolaimidae;
OC   Panagrolaimus.
OX   NCBI_TaxID=591445 {ECO:0000313|Proteomes:UP000887579, ECO:0000313|WBParaSite:ES5_v2.g17381.t1};
RN   [1] {ECO:0000313|WBParaSite:ES5_v2.g17381.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-imidazolone-5-propanoate = trans-urocanate + H2O;
CC         Xref=Rhea:RHEA:13101, ChEBI:CHEBI:15377, ChEBI:CHEBI:17771,
CC         ChEBI:CHEBI:77893; EC=4.2.1.49;
CC         Evidence={ECO:0000256|ARBA:ARBA00047623};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004794}.
CC   -!- SIMILARITY: Belongs to the urocanase family.
CC       {ECO:0000256|ARBA:ARBA00007578}.
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DR   WBParaSite; ES5_v2.g17381.t1; ES5_v2.g17381.t1; ES5_v2.g17381.
DR   Proteomes; UP000887579; Unplaced.
DR   GO; GO:0016153; F:urocanate hydratase activity; IEA:InterPro.
DR   GO; GO:0006548; P:L-histidine catabolic process; IEA:TreeGrafter.
DR   FunFam; 3.40.1770.10:FF:000002; Urocanate hydratase 1; 1.
DR   FunFam; 3.40.1770.10:FF:000003; Urocanate hydratase 1; 1.
DR   FunFam; 3.40.50.10730:FF:000002; Urocanate hydratase 1; 1.
DR   Gene3D; 3.40.50.10730; Urocanase like domains; 1.
DR   Gene3D; 3.40.1770.10; Urocanase superfamily; 2.
DR   HAMAP; MF_00577; HutU; 1.
DR   InterPro; IPR055351; Urocanase.
DR   InterPro; IPR023637; Urocanase-like.
DR   InterPro; IPR035401; Urocanase_C.
DR   InterPro; IPR038364; Urocanase_central_sf.
DR   InterPro; IPR023636; Urocanase_CS.
DR   InterPro; IPR035400; Urocanase_N.
DR   InterPro; IPR035085; Urocanase_Rossmann-like.
DR   InterPro; IPR036190; Urocanase_sf.
DR   NCBIfam; NF003820; PRK05414.1; 1.
DR   PANTHER; PTHR12216; UROCANATE HYDRATASE; 1.
DR   PANTHER; PTHR12216:SF3; UROCANATE HYDRATASE; 1.
DR   Pfam; PF01175; Urocanase; 1.
DR   Pfam; PF17392; Urocanase_C; 1.
DR   Pfam; PF17391; Urocanase_N; 1.
DR   PIRSF; PIRSF001423; Urocanate_hydrat; 1.
DR   SUPFAM; SSF111326; Urocanase; 1.
DR   PROSITE; PS01233; UROCANASE; 1.
PE   3: Inferred from homology;
KW   Histidine metabolism {ECO:0000256|ARBA:ARBA00022808};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000887579}.
FT   DOMAIN          87..212
FT                   /note="Urocanase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17391"
FT   DOMAIN          215..435
FT                   /note="Urocanase Rossmann-like"
FT                   /evidence="ECO:0000259|Pfam:PF01175"
FT   DOMAIN          438..646
FT                   /note="Urocanase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17392"
SQ   SEQUENCE   673 AA;  75005 MW;  D8F10E41DEE1D66B CRC64;
     MDIQHLINED LFDPLIEYPH EQRKVDVPHA PKRAVPLDTD GKKLAVRNIL RYVPTKHHDV
     LAKEFADELK TYGHIYAFRF MPKFNLNAIP IDQIPANSQQ AAAIILMILN NLDPSVAQFP
     QELVTYGGNG QVFSNWLQFR LVIKYLAEMT EEQTLSLYSG HPLGLFPSHE HAPRVVITNG
     MMIPNYSTKE YYDKFFALGV TQYGQMTAGS YCYIGPQGIV HGTTITVMNA GRKYLSTESL
     AGKVFLTSGL GGMSGAQAKA AVISGCVGVI AEISEKALLK RHHQGWLDIY SDNLDTVISH
     IKEYRQNKQA VSIGYLGNVV DLWEKLAKEN ELLVELGSDQ TSCHNPYNGG YYPVGLTFDE
     ANKMMSENPK GFEKQVKESL RRQITAIDTL AAKGMHFWDY GNAFLLECHR AGADVLAKDA
     KDDKSFKYPS YMQDIMGDIF SLGFGPFRWV CTSGLEEDLQ LTDKIAAEVI TKLSKQNDVS
     DATRQQYDDN RHWIEKAEEH KLVVGSKARI LYSDQEGRIE IALAFNKAVR EKRLKAPIVI
     SRDHHDVSGT DSPFRETSNI SDGSAYTADM AVQNAIGDAF RGATWISLHN GGGVGWGDVI
     NGGFGMVLDG SEKSDWRAGL MLNWDVSNGV ARRSWSGNDN GYETIKRTMQ NVPGLKVTLP
     NKVEDNILDK AFN
//