ID A0A914M9G7_MELIC Unreviewed; 810 AA.
AC A0A914M9G7;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=E3 UFM1-protein ligase 1 homolog {ECO:0000256|ARBA:ARBA00014160};
DE AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000256|ARBA:ARBA00030452};
OS Meloidogyne incognita (Southern root-knot nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne; Meloidogyne incognita group.
OX NCBI_TaxID=6306 {ECO:0000313|Proteomes:UP000887563, ECO:0000313|WBParaSite:Minc3s01380g23309};
RN [1] {ECO:0000313|WBParaSite:Minc3s01380g23309}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC proteins. {ECO:0000256|ARBA:ARBA00003950}.
CC -!- SIMILARITY: Belongs to the UFL1 family.
CC {ECO:0000256|ARBA:ARBA00010789}.
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DR WBParaSite; Minc3s01380g23309; Minc3s01380g23309; Minc3s01380g23309.
DR Proteomes; UP000887563; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:TreeGrafter.
DR GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR GO; GO:1990592; P:protein K69-linked ufmylation; IEA:TreeGrafter.
DR GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:TreeGrafter.
DR InterPro; IPR018611; Ufl1.
DR InterPro; IPR056761; Ufl1-like_C.
DR InterPro; IPR056580; Ufl1_dom.
DR InterPro; IPR056579; Ufl1_N.
DR PANTHER; PTHR31057; E3 UFM1-PROTEIN LIGASE 1; 1.
DR PANTHER; PTHR31057:SF0; E3 UFM1-PROTEIN LIGASE 1; 1.
DR Pfam; PF09743; E3_UFM1_ligase; 1.
DR Pfam; PF23659; UFL1; 1.
DR Pfam; PF25041; UFL1_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000887563};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 9..292
FT /note="E3 UFM1-protein ligase 1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09743"
FT DOMAIN 566..684
FT /note="E3 UFM1-protein ligase 1-like"
FT /evidence="ECO:0000259|Pfam:PF23659"
FT DOMAIN 696..782
FT /note="E3 UFM1-protein ligase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF25041"
FT REGION 429..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 541..573
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 430..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 92819 MW; 6291B1C1E8E2EAA7 CRC64;
MTSTTSWADI QRLAADLQRV QLAESNKQRL TESNCVEVIS MLISMGFIDL VISSDGKEYV
TRKHLQTECA NECLAAGGRI SLTDLASQLN VNLDHISGAV NQLVRQIDHE EDHVNISTSN
DFLICAGELI HRDFINGLCA KLNEQLEELG TISMLQLTRQ WELPTELLNQ HILTELGTGR
ISAIRFEDYL CTNRYINTLK GKFRAILIGL TKPCPLTEIY SYLAVSESFF FLLLNELNDQ
GKLPGKLLGT KNSIKSLYVP FIHERMAKQF ILQRLSEEHF IECSIMKRLS ISGEPISFFR
ELLPSTEFND LLFWPSVVLS ESLLWKECDL LAKNLLHSIH FCLIDDILPV KLISVFNDSD
YIKIVEILQK GWNEGYLRTT NDRRVIFDHS KLISNWLKSI EEFIHERAVK DAPELRKAQL
NAAISIQKQL NKEEKKQQKD DDWEIEKPSK GGKGANKKNR SGGGSSHQTS SRSGKQKAAT
ESNISNKDLL SCASPFSSDE LFTELERCHS SSDFQIPDTL REEIADDFIA EVNNLYRRFV
TEEWEQQLHQ TTAEEQQAQR QAFEQRLNKI SDEYAAICLF EKGTDYFEED QLANDLRIYL
LRSLCTELSH SLLYTISDLN LSQQSSPKPT ILNNKQRDHL IDSLESIEMQ KCSRQLFNSF
DTLEHFHEAF QRLTAMNGLK LKQPDRKERT QKLDLFGKEL HKQMLECTDP PTTLLLTVIL
CFQLYYRIAI HASGKFVSPL IHFLSTGTSA IPPDLVNLLN EIQHLVVASI KHKGDSSEKI
KNDLMEKLVN LKTFFSYSDQ EEKHEEKEKE
//
