ID   A0A914MIG3_MELIC        Unreviewed;       513 AA.
AC   A0A914MIG3;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   05-FEB-2025, entry version 8.
DE   SubName: Full=SH2 domain-containing protein {ECO:0000313|WBParaSite:Minc3s01952g27387};
OS   Meloidogyne incognita (Southern root-knot nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC   Meloidogyne; Meloidogyne incognita group.
OX   NCBI_TaxID=6306 {ECO:0000313|Proteomes:UP000887563, ECO:0000313|WBParaSite:Minc3s01952g27387};
RN   [1] {ECO:0000313|WBParaSite:Minc3s01952g27387}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
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DR   WBParaSite; Minc3s01952g27387; Minc3s01952g27387; Minc3s01952g27387.
DR   Proteomes; UP000887563; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000887563};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          39..133
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          344..453
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          462..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  58602 MW;  FD4F0C91BBD91949 CRC64;
     MFEQPQHSSS LTPSLSDNSI SGMTNNSMLN SQTLEEYCWY WGAASKEEIS AAMENQQNGT
     FAVRDASTKG QYTLTLRIDG TNKLIKILVE NGRCGFTQDS MDFDSMASLV QFYQTCSLRD
     FNEKLDTCLL YPLNSPQSLT CQNSMKSDST IDPSYRVSLL KCTFEAIHAE YDRVSRRYDQ
     LFNQQLALNE EYNRKQRTES AYADVLKIFE RKIAELKTTI SGEKDLNDRD RESLTINIEL
     QEERMEEIGK AQNLMRAAIQ NIGLSLQKIN EELGRLKPLL LKLHKKCEKY RDKLLEMSKQ
     KVTHAQLDRV VQSVSLALDS EPSTLSTFLL RISLPMSNWC CECWLWHQAT KDESIALIRS
     LMNDFDNSNA STDGIFLIRP SSSRIGFYAL EISKDGNVHS CLVEYRDPRT TIDHSGGYGF
     AQTQMLFASL MDFVRYYSAV PLKEHNSVLD TPLITPALSQ LKQRKEKNNS NTSNTDHQRD
     KAKLKRIEAI DDATELSTSR DDERSKEKIL DTL
//