ID A0A914N0W1_MELIC Unreviewed; 457 AA.
AC A0A914N0W1;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 05-FEB-2025, entry version 10.
DE SubName: Full=Sodium/nucleoside cotransporter {ECO:0000313|WBParaSite:Minc3s02687g31193};
OS Meloidogyne incognita (Southern root-knot nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne; Meloidogyne incognita group.
OX NCBI_TaxID=6306 {ECO:0000313|Proteomes:UP000887563, ECO:0000313|WBParaSite:Minc3s02687g31193};
RN [1] {ECO:0000313|WBParaSite:Minc3s02687g31193}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR WBParaSite; Minc3s02687g31193; Minc3s02687g31193; Minc3s02687g31193.
DR Proteomes; UP000887563; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005415; F:nucleoside:sodium symporter activity; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000887563};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..88
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 104..201
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 206..415
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 457 AA; 49862 MW; 0F0A3718227A2955 CRC64;
MIWDCRNTPH RLTGLVGLTF FVIILCLCSH KPSKINWRPV LWGFLLQFIF GIIVLRWDWG
TNKFSEIANL IISILDFTFH GTDFAYGFLS SPPNICGMHP VLAFKILQVI IYVGALVSVL
YFYGIIQAVL KRLAWLMQFT MGTTATESLN ACGCVFLGNA ESPLLIRPYI EKMTNSELHA
LITTGFSCIA GAVFAVFISF GACPRYLLSA AVMGAPGSLA CSKLLYPETE ESITKGVDDL
DLPPSEKKNA MESISSGSTE AIHLVNCLVA SMITFISLTA LISGIIEYAG SLLGYPGWSL
ELLFGYALFP IAYLIGVTDG MDQALLVGRL LGIKIAVSDF LSFKQLGEIL HLLTPRTAMI
ATYSLCSFSN LIAAGAQMAI IGGIAPKTKP IISKLIMSAL LGGNITCFIS ACIAGILIED
PILCQKTYGI QSENCFDINL HQKFMEEIIR QRNITLN
//
