ID A0A914Q4F7_9BILA Unreviewed; 210 AA.
AC A0A914Q4F7;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
OS Panagrolaimus davidi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Panagrolaimoidea; Panagrolaimidae;
OC Panagrolaimus.
OX NCBI_TaxID=227884 {ECO:0000313|Proteomes:UP000887578, ECO:0000313|WBParaSite:PDA_v2.g25738.t1};
RN [1] {ECO:0000313|WBParaSite:PDA_v2.g25738.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] +
CC acetate; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|ARBA:ARBA00048287};
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR AlphaFoldDB; A0A914Q4F7; -.
DR WBParaSite; PDA_v2.g25738.t1; PDA_v2.g25738.t1; PDA_v2.g25738.
DR Proteomes; UP000887578; Unplaced.
DR GO; GO:0016581; C:NuRD complex; IEA:TreeGrafter.
DR GO; GO:0141221; F:histone deacetylase activity, hydrolytic mechanism; IEA:UniProtKB-EC.
DR GO; GO:0031507; P:heterochromatin formation; IEA:TreeGrafter.
DR CDD; cd09991; HDAC_classI; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR003084; HDAC_I/II.
DR InterPro; IPR000286; HDACs.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF10; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000887578};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 28..207
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 210 AA; 24605 MW; F38530C3C4AC6964 CRC64;
MSVQNHFKRR IAYYYDGDVG NYYYGQGHPM KPHRIRMCHN LLLNYGLYRK MEIFRPRPAE
MEELTRYHSD DYMLFLQNIR PDNINDYTKQ MQRFNVGEDC PVFDGLYEFC QISSGGSIAA
AQKINEGHSD IAINWMGGLH HAKKSEASGF CYSNDIVLAI LELLKVHPRV LYVDIDIHHG
DGVEEAFYTT DRVMTCSFHK YGEYFPGEYW
//
