ID   A0A914S6Y0_PAREQ        Unreviewed;       500 AA.
AC   A0A914S6Y0;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   28-JAN-2026, entry version 11.
DE   RecName: Full=DNA primase large subunit {ECO:0000256|ARBA:ARBA00019038};
OS   Parascaris equorum (Equine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Parascaris.
OX   NCBI_TaxID=6256 {ECO:0000313|Proteomes:UP000887564, ECO:0000313|WBParaSite:PEQ_0001294401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:PEQ_0001294401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the eukaryotic-type primase large subunit
CC       family. {ECO:0000256|ARBA:ARBA00010564}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; PEQ_0001294401-mRNA-1; PEQ_0001294401-mRNA-1; PEQ_0001294401.
DR   Proteomes; UP000887564; Unplaced.
DR   GO; GO:0005658; C:alpha DNA polymerase:primase complex; IEA:TreeGrafter.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:TreeGrafter.
DR   GO; GO:0006269; P:DNA replication, synthesis of primer; IEA:UniProtKB-KW.
DR   CDD; cd07322; PriL_PriS_Eukaryotic; 1.
DR   Gene3D; 1.20.930.80; -; 1.
DR   InterPro; IPR058560; DNA_primase_C.
DR   InterPro; IPR016558; DNA_primase_lsu_euk.
DR   InterPro; IPR007238; DNA_primase_lsu_euk/arc.
DR   PANTHER; PTHR10537; DNA PRIMASE LARGE SUBUNIT; 1.
DR   PANTHER; PTHR10537:SF3; DNA PRIMASE LARGE SUBUNIT; 1.
DR   Pfam; PF04104; DNA_primase_lrg; 1.
DR   Pfam; PF26466; DNA_primase_lrg_N; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515};
KW   Reference proteome {ECO:0000313|Proteomes:UP000887564}.
FT   DOMAIN          310..445
FT                   /note="DNA primase large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04104"
FT   REGION          460..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..478
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..494
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  57506 MW;  6E9621D34BFF344D CRC64;
     MLPLRAVVVN AKRRWFSRDD PFRAVPLLAV KNFKPWELIL SYFKMQFESS SRIVRKSFIS
     GARIALQKEL MKLMPIAXXX TKWFIQQEID LFKYRFHMES KNRANIARFL ATNHFNMTAL
     TQVEKDQLAE KIANANGVST QMVRESQSSN LFNISTDQWC RSILKVRCVD VWKVPFVDAL
     DLVRRRRVFL HAGFAYVSRD DLVVIVCTKL RMNMSSAMAR ACKYIGFIEE EHRLMPLLLK
     LTNKAYVGKD YAGEDTTKRI TPEMIXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXYPFMSK GIGLTLEDAL AFWRAEFTKK IDADRFDKQY AYNIRHNYGK EGRRVNYKAY
     SCSKIILGSA PSAQDCHGCP YRHSDPTVLA QKLEGVGLSK EHIATIVNLS KTAQYDRACT
     RYFEFTHKMA ENSLGVLITH PNQYFELSTQ VHEGIRSRET VPTHEVTLSS STQQSTLSAE
     RTEEEDDYDF DDMTEADKAC
//