ID A0A914WRS9_9BILA Unreviewed; 1311 AA.
AC A0A914WRS9;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 02-APR-2025, entry version 12.
DE SubName: Full=Zinc-hook domain-containing protein {ECO:0000313|WBParaSite:PSAMB.scaffold5007size12906.g25686.t1};
OS Plectus sambesii.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Plectida; Plectina;
OC Plectoidea; Plectidae; Plectus.
OX NCBI_TaxID=2011161 {ECO:0000313|Proteomes:UP000887566, ECO:0000313|WBParaSite:PSAMB.scaffold5007size12906.g25686.t1};
RN [1] {ECO:0000313|WBParaSite:PSAMB.scaffold5007size12906.g25686.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00049360};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR WBParaSite; PSAMB.scaffold5007size12906.g25686.t1; PSAMB.scaffold5007size12906.g25686.t1; PSAMB.scaffold5007size12906.g25686.
DR Proteomes; UP000887566; Unplaced.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:TreeGrafter.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:TreeGrafter.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IEA:TreeGrafter.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:TreeGrafter.
DR GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:TreeGrafter.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IEA:TreeGrafter.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75712; Rad50 coiled-coil Zn hook; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000887566};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 640..737
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT REGION 589..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 255..292
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 399..543
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 743..862
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 967..1008
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1051..1099
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 684
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 687
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1311 AA; 151191 MW; 93B52FB71C24B068 CRC64;
MASFDSLWVQ GIRSVGSGDD CAQMIQFQRP LTLITGPNGS GKTTLIEALK YVTAGELPPG
KLAAFIHDPK VANKIRVDAS VKLEFEDTTG RRCVATRRLY AQIKKQKVEC RSDEATIKYT
DANGMERSIN SKVADFDKEM GNLLGVSKAV LNYVIFCHQE ESSWPLGEPK ELKTKFDAIF
QADRYVKAIE SMNKVRKEYT TELKIIQTKL VYMHGDYSEK LKMTRALQKD KQEQASNEER
RDELATGLRP LTVRLNELNG YMESMRLAIQ EMEKLKAELS EKSHRLNELQ RQIDTPYPGT
RSDLEREIRQ MKEGGWNVEE EGRRCQDQID RLKSEMDTVD AARQRLTRQL GMHEANARQR
TEAVSQRDEL MLSLAKQHRI TDFFAAQSPF EEDAVKRFET RLELENSALT SQRNDAESNH
RERDEMLVRQ LNNCVSETAK VEQTIETKRR DADRHREEAD RIAIELKHIA SSQNELAKLD
RDIQEQERQF TALEGSFNEA AGQGRITALK QQRQQLRDKI VDLENESKNA QGQFTQRNQL
EEKRKLRSKI AGECDDIIGR HRATLVDLLG SVPEYSFKGA VEEKTMELTR TRQEKESALR
AKDGEVSNWE QKRRSLQQQL TKKEADRSEH NVAILKVTNG DDLDTKLAEV DKLLVKYRNE
KGTIEGGKFV YEGYIESVQQ RQCCPLCERD YNSANESKKL IDKISRKIKN APAELTTLER
KIVESEELRT KLISVQPIVD LVRNIAETEL PELNNSLEEA SEILIGLRRE RETLENELDR
VKRDEHALRP VEADASLVDR HRRTVNDLDA EIEQLTKLLG MALSVRDSDT IQREVEDSRK
TLSELEEEVE AKQAALDAER TQFINVKEAL NTLRTERLTI LEKSHKVDAL KTKREEHEVL
LKKCAAEEEQ ARVQLAPFQR KIQDLKTDRE RIALEYKNRS EEINSAARSL LAAIDQFNSL
NANVRRLTQA AADMDRCSDE LQQTNDRRDQ LSNEKSATDA KLTAIKEQLD SRDWRMRKLN
DHLSLMDLTV RVDELESKIS IKQAAFGDKT EEQLSEERRQ LIDKIDAINR NVHKLEGSLD
ELRKKIKEAE RRLHEERYRK AGENWRQAKV EEVTVREVIK DLSKYAKALD MAIINYHSSK
MEEINAILAD LWRRVYKGND IDCIKIKSEG VEEGEKRRAY NYRVVMSVDG NEIDMRGRCS
AGQKVLASIL IRLALADVFC LNCGMIALDE PTTNLDFQKV ENLAEALNNL IAMRGEQANF
QLVVITHDER LVEHLARNYR PDFMYGVKKN YKGHTIIRRH RDLDELQDEE D
//
