ID A0A915A9X0_PARUN Unreviewed; 1001 AA.
AC A0A915A9X0;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Valine--tRNA ligase {ECO:0000256|ARBA:ARBA00024407};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
OS Parascaris univalens (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Parascaris.
OX NCBI_TaxID=6257 {ECO:0000313|Proteomes:UP000887569, ECO:0000313|WBParaSite:PgR002_g282_t01};
RN [1] {ECO:0000313|WBParaSite:PgR002_g282_t01}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP +
CC diphosphate; Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA-
CC COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00047552};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR AlphaFoldDB; A0A915A9X0; -.
DR WBParaSite; PgR002_g282_t01; PgR002_g282_t01; PgR002_g282.
DR Proteomes; UP000887569; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0002161; F:aminoacyl-tRNA deacylase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR CDD; cd00817; ValRS_core; 1.
DR FunFam; 3.40.50.620:FF:000119; Putative valine--tRNA ligase-like; 1.
DR FunFam; 1.10.730.10:FF:000009; Valine--tRNA ligase, mitochondrial; 1.
DR FunFam; 3.40.50.620:FF:000020; Valine--tRNA ligase, mitochondrial; 1.
DR FunFam; 3.90.740.10:FF:000005; Valine--tRNA ligase, mitochondrial; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.730.10; Isoleucyl-tRNA Synthetase, Domain 1; 1.
DR Gene3D; 1.10.287.380; Valyl-tRNA synthetase, C-terminal domain; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR HAMAP; MF_02004; Val_tRNA_synth_type1; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR037118; Val-tRNA_synth_C_sf.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; NF004349; PRK05729.1; 1.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF109; VALINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000887569}.
FT DOMAIN 43..671
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 716..869
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT COILED 931..958
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1001 AA; 113996 MW; 1975641C8AB4D6E8 CRC64;
EREAKKPKVD VVEYKGTTKI GEKKDTSMEI PNAYSPKYVE AAWYDWWEKE GFFRPEYDGR
DLRKPNPKGS FTIVIPPPNV TGTLHLGHAL ATSVEDTLCR WHRMKGKTVL FNPGCDHAGI
ATQVVVEKRL KKERGLTRHD LGREKFIEEV WKWKDEKGVI IYDQLRKMGA GVDWERACFM
MDPKMMRAVT HAFVDMHDRG VIYRSNRLVN WSCTLRSAIS DIEVDKIELS GRTLLSVPGY
SKKVEFGVLV SFAYPVEGSD EEVVVATTRV ETMLGDTAIA VHPDDDRYEH LIGKFCKHPF
VDRRLPIVAD SFVEKEFGTG AVKITPAHDH NDYGVGVRHN LPFITIFTDD GEMNDKCGEF
KGMKRFEARE AVLEALKKKG LYRDVKDNPM IVPICSRSKD VIEPILKSQW YVRCDMMAER
AKEAVARGEL VIIPDYHVAT WNRWLDSMRD WCISRQLWWG HRIPAYFVTV DDPSVPAGDS
DDNNYWVSAH NEGEAIEKAA KKFNVPKEKI SVKWDEDVLD TWFSSGMWPF TIFGWPEKTS
DLRNFFPGSV LETGHDILFF WVARMVFMSQ ELTGQLPFKE IYLHAMIRDA HGRKMSKSLG
NVIDPIDVIH GISLAQLNKQ LESGNLDAKE LKTAKEGQAR DYPNGIPECG TDALRFALMV
YTSQGRDINL DVLRVQGYRF FCNKIWQASK FTLMQLGNDF KPLAEFKLSG SESTLDKWIL
SRLSFAVETC NAAMSSYTFH QATSAMYNFW LYDFCDIYIE GSKPVLLNGG ANVVSTTRQI
LYTCVDTGLR LISPIMPFIS EELWQRLPRR PSAHKQPLSI CVAEYPEVEE YKYRNELLEN
RVSRVMDIVK TVRSLRSDYD LTAKVKADLY VTFMEKEEAD AVGDLVTLIS TLTSSQMVSI
LTGDQDSEIP KGCAQITVSA RCKASLALQD IIDVAKELAK LGEKKTKLES QLDKLDEIMS
KRDYEQKVPL GVRTNNAEKK DSLCIELKHI NEAIAALEAS E
//
