ID A0A915CMU1_9BILA Unreviewed; 211 AA.
AC A0A915CMU1;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 9.
DE RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC1 {ECO:0000256|ARBA:ARBA00020809};
DE AltName: Full=RPB5 homolog {ECO:0000256|ARBA:ARBA00032836};
OS Ditylenchus dipsaci.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Sphaerularioidea; Anguinidae; Anguininae;
OC Ditylenchus.
OX NCBI_TaxID=166011 {ECO:0000313|Proteomes:UP000887574, ECO:0000313|WBParaSite:jg10650};
RN [1] {ECO:0000313|WBParaSite:jg10650}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
CC Pol II is the central component of the basal RNA polymerase II
CC transcription machinery. Pols are composed of mobile elements that move
CC relative to each other. In Pol II, RPB5 is part of the lower jaw
CC surrounding the central large cleft and thought to grab the incoming
CC DNA template. Seems to be the major component in this process.
CC {ECO:0000256|ARBA:ARBA00060082}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit
CC is present in 2-fold molar excess over the other subunits.
CC {ECO:0000256|ARBA:ARBA00064429}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase
CC subunit family. {ECO:0000256|ARBA:ARBA00025765}.
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DR WBParaSite; jg10650; jg10650; jg10650.
DR Proteomes; UP000887574; Unplaced.
DR GO; GO:0005736; C:RNA polymerase I complex; IEA:TreeGrafter.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:TreeGrafter.
DR GO; GO:0006362; P:transcription elongation by RNA polymerase I; IEA:TreeGrafter.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:TreeGrafter.
DR FunFam; 3.40.1340.10:FF:000001; DNA-directed RNA polymerases I, II, and III subunit RPABC1; 1.
DR FunFam; 3.90.940.20:FF:000001; DNA-directed RNA polymerases I, II, and III subunit RPABC1; 1.
DR Gene3D; 3.40.1340.10; RNA polymerase, Rpb5, N-terminal domain; 1.
DR Gene3D; 3.90.940.20; RPB5-like RNA polymerase subunit; 1.
DR HAMAP; MF_00025; RNApol_Rpo5_RPB5; 1.
DR InterPro; IPR014381; Arch_Rpo5/euc_Rpb5.
DR InterPro; IPR005571; RNA_pol_Rpb5_N.
DR InterPro; IPR036710; RNA_pol_Rpb5_N_sf.
DR InterPro; IPR000783; RNA_pol_subH/Rpb5_C.
DR InterPro; IPR020608; RNA_pol_subH/Rpb5_CS.
DR InterPro; IPR035913; RPB5-like_sf.
DR NCBIfam; NF007129; PRK09570.1; 1.
DR PANTHER; PTHR10535; DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1; 1.
DR PANTHER; PTHR10535:SF0; DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1; 1.
DR Pfam; PF01191; RNA_pol_Rpb5_C; 1.
DR Pfam; PF03871; RNA_pol_Rpb5_N; 1.
DR PIRSF; PIRSF000747; RPB5; 1.
DR SUPFAM; SSF53036; Eukaryotic RPB5 N-terminal domain; 1.
DR SUPFAM; SSF55287; RPB5-like RNA polymerase subunit; 1.
DR PROSITE; PS01110; RNA_POL_H_23KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000887574};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 6..95
FT /note="RNA polymerase Rpb5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03871"
FT DOMAIN 138..210
FT /note="RNA polymerase subunit H/Rpb5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01191"
SQ SEQUENCE 211 AA; 24460 MW; D2A1F1433878140B CRC64;
MADDEMECYK LWRVRKTVMQ MCHDRGYLVT QEELDQTIDD FKLHFGDRPS ERHPGRSDLT
ILVAHNDDPT DQMFVFFPED PKIGIKTIKA ICQQMQEQSI TRAIIVVQTG MTPSAKQAIG
DMAPKYTLEH FQEAELMVNI TEHELVPEHV VMTSDEKAEL LARYKLKDNQ LPRIQISDPV
ARYFGLKRGQ VVKIIRPSET AGRYITYRLC F
//
