ID   A0A915D3M1_9BILA        Unreviewed;       591 AA.
AC   A0A915D3M1;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   28-JAN-2026, entry version 12.
DE   SubName: Full=PD-(D/E)XK endonuclease-like domain-containing protein {ECO:0000313|WBParaSite:jg15565};
OS   Ditylenchus dipsaci.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Sphaerularioidea; Anguinidae; Anguininae;
OC   Ditylenchus.
OX   NCBI_TaxID=166011 {ECO:0000313|Proteomes:UP000887574, ECO:0000313|WBParaSite:jg15565};
RN   [1] {ECO:0000313|WBParaSite:jg15565}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A915D3M1; -.
DR   WBParaSite; jg15565; jg15565; jg15565.
DR   Proteomes; UP000887574; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   InterPro; IPR051827; Cas4_exonuclease.
DR   InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   PANTHER; PTHR36531; CRISPR-ASSOCIATED EXONUCLEASE CAS4; 1.
DR   PANTHER; PTHR36531:SF6; DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2; 1.
DR   Pfam; PF08696; Dna2; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000887574}.
FT   DOMAIN          196..255
FT                   /note="DNA replication factor Dna2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08696"
FT   DOMAIN          322..444
FT                   /note="PD-(D/E)XK endonuclease-like"
FT                   /evidence="ECO:0000259|Pfam:PF12705"
SQ   SEQUENCE   591 AA;  65818 MW;  45A9DFF111534F70 CRC64;
     MCTRPHSQYW TRHSYAIMNI PSALKIGSQS PGKDDSWSSW DEDEEVQCVK SNHSATNKEN
     QPVLATESMQ CKSSDALDGS FRRSSKLVLR DVTLPKEGSA KRAAALMLDQ TQNGISCEIK
     RFRSSESIGA NYNKTSPHRP VKTRPKSTKL LQNSSTINGF PALNNYENHV LLKVVSVEQI
     AGAFKIVGHQ LFGQSSLTVL LKDMWRNSVF PAGSMLRLID PLKLSETVYE VSANLGLLIV
     EPETLLSSTA MAQALNVVHE LFQFSIAKRP AQFSEKFLLD KWIPASLKIS FDPKCLKPLT
     KKSPVCLNHL EDIEDCIWTP TIGFKGKIDV SYRANSSVVK QDVRALELKT GKSYAGSIEH
     QTQVLIYSLM LSENCNSGRI LPANVLYLKD NQARQVDPLA GELKGILQMR NRLAPSFAHL
     SLNSLPAPLT AARQCSSCQF AVTCALADRS TSSSQRLIDY DLTSDMDAFF KKSLDHLNLE
     EIKYASQWTE WLFAEWRSAK AKSEDVRLFR ESPDQRQLHG SCLANLRLNT SCEVEGYRSS
     YLLTFSREDG SSVLHDSMEK LPFEVGNMIV VSTSSAYALI MGSVHSIRGS V
//