ID   A0A915HUK9_ROMCU        Unreviewed;       634 AA.
AC   A0A915HUK9;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   02-APR-2025, entry version 9.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS   Romanomermis culicivorax (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia; Mermithida;
OC   Mermithoidea; Mermithidae; Romanomermis.
OX   NCBI_TaxID=13658 {ECO:0000313|Proteomes:UP000887565, ECO:0000313|WBParaSite:nRc.2.0.1.t05097-RA};
RN   [1] {ECO:0000313|WBParaSite:nRc.2.0.1.t05097-RA}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   WBParaSite; nRc.2.0.1.t05097-RA; nRc.2.0.1.t05097-RA; nRc.2.0.1.g05097.
DR   Proteomes; UP000887565; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20338; BRcat_RBR_RNF19; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 1.
DR   Pfam; PF22191; IBR_1; 1.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000887565};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        380..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          152..370
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          156..206
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          110..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..144
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  70007 MW;  F6A68A89916D1D19 CRC64;
     MFSRKKAAKK TSNPSVVTPS LLVPLTSISA QKSPNIVTKP PQTEPRTQTN ISNDELTAKI
     ESKKRRRSLL GGSRLSVYSL FYPSAYSNRR LSRPIGSRSV NDIHNAVVVE QHQNNNGEHN
     ENDVTSSSER ENLMSSSSSS TANNNLNSVK SKFQECPLCC IRQPMDNFPT LLSCNHRSCR
     SCLVQIYYLQ IDILESRVLI ACPECNELMH PNDIQRLLLN HRQVLDKYEE FSVRRVLMID
     PDTRWCPSPD CNFAVIASGC AACPELKCER PGCNTLFCYH CKMIWHPSQT CTEARAQRGS
     LAQSTVQVDT TVKPGDVKPC PRCRAYITKA DDGSCNHMVC SMCGAEFCWL CMKEISDLHY
     LSPSGCTFWA KKPWSRKKKL IWQFGMLIGA PIGIALVAGF AVPAIMFGVP VWIGRKVHTK
     LKNSSKTKRR AAVTLSVAGS ILMGPALATM AVGVGVPIML AYVYGVVPLS LCRNGSCGVT
     ASPSGVRLDL DSDLFEPNEA LDSVSHEKTQ LLTNGDRSDV ITMISGRSGT ASINQHKIQV
     HAEMAYVAKR RPSIESGAIS LGDRQNYEDA SVQALGGSVY YDDKNKHKQS FFVRSPQLTD
     SGRNLSTWNK VDFELNAEPY INPLLVTTGP ENVI
//