ID A0A915N550_MELJA Unreviewed; 160 AA.
AC A0A915N550;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 05-FEB-2025, entry version 7.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11 {ECO:0000256|ARBA:ARBA00019621, ECO:0000256|RuleBase:RU364147};
DE AltName: Full=Mediator complex subunit 11 {ECO:0000256|ARBA:ARBA00032011, ECO:0000256|RuleBase:RU364147};
GN Name=MED11 {ECO:0000256|RuleBase:RU364147};
OS Meloidogyne javanica (Root-knot nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne; Meloidogyne incognita group.
OX NCBI_TaxID=6303 {ECO:0000313|Proteomes:UP000887561, ECO:0000313|WBParaSite:scaffold6922_cov210.g11462};
RN [1] {ECO:0000313|WBParaSite:scaffold6922_cov210.g11462}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2022) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional pre-initiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364147}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000256|ARBA:ARBA00008186, ECO:0000256|RuleBase:RU364147}.
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DR WBParaSite; scaffold6922_cov210.g11462; scaffold6922_cov210.g11462; scaffold6922_cov210.g11462.
DR Proteomes; UP000887561; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.287.3490; -; 1.
DR InterPro; IPR019404; Mediator_Med11.
DR PANTHER; PTHR22890; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11; 1.
DR Pfam; PF10280; Med11; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364147};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364147};
KW Reference proteome {ECO:0000313|Proteomes:UP000887561};
KW Transcription {ECO:0000256|RuleBase:RU364147};
KW Transcription regulation {ECO:0000256|RuleBase:RU364147}.
FT REGION 139..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18086 MW; 1B9D16B7130AD04D CRC64;
MASTSALPET APPVEQMMEE ISADTETIQL EQRLECLKDV DWKVAELMAI VAEVLNSLEK
DKPISKSKME DLYKRYETKL DEVQKGVGEQ LTYMEQVCVG AEHQGSNFHA KQVAELSGKR
LQSLNNQLEN IKNLINSENE EGNKLGIEAE QDDENMEEEL
//
