ID A0A917HFS2_9BACI Unreviewed; 630 AA.
AC A0A917HFS2;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=GCM10011398_22910 {ECO:0000313|EMBL:GGG77252.1};
OS Virgibacillus oceani.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Virgibacillus.
OX NCBI_TaxID=1479511 {ECO:0000313|EMBL:GGG77252.1, ECO:0000313|Proteomes:UP000622860};
RN [1] {ECO:0000313|EMBL:GGG77252.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.12754 {ECO:0000313|EMBL:GGG77252.1};
RX PubMed=25193709;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Walter F., Albersmeier A., Kalinowski J., Ruckert C.;
RT "Complete genome sequence of Corynebacterium casei LMG S-19264T (=DSM
RT 44701T), isolated from a smear-ripened cheese.";
RL Int. J. Syst. Evol. Microbiol. 189:76-77(2014).
RN [2] {ECO:0000313|EMBL:GGG77252.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.12754 {ECO:0000313|EMBL:GGG77252.1};
RA Sun Q., Zhou Y.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GGG77252.1}.
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DR EMBL; BMFR01000009; GGG77252.1; -; Genomic_DNA.
DR RefSeq; WP_188455540.1; NZ_BMFR01000009.1.
DR AlphaFoldDB; A0A917HFS2; -.
DR Proteomes; UP000622860; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 2.40.30.10:FF:000020; Translation elongation factor EF-1; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:GGG77252.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000622860}.
FT DOMAIN 3..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 630 AA; 71590 MW; DBDD3A627C334CFE CRC64;
MESRYYTIGM AGHIDHGKTT LTKALTNIDT DRLKEEKERK ISIELGYAPL QTKDGTHVSI
VDVPGHERFI RQMIAGVAGI DLVVLVIAAD EGVMPQTKEH LEILEFLGVK RCIVAVTKID
RVDEELLELV GMDISEALAE TSFKDAPMVY VDSVTSVGVE QLKEKIFTEL KSVEFRDRHG
SFRLPIDQVF TVQGQGTVVR GTIYEGVVTT GSQLIVLPSG QKVKARNIQV HHNNVKEASA
GQRTAINLGG INRSELKRGD VLVATDHFLV SDTIDVLVRF VRDLQAAIKQ RSPVKLHVGT
SEVTGKIIFF DRNVIQEATD EVLCQIRLDN SIVVRRGDRF ILRRPTPAET IGGGWIIDPN
SQKYPFGQQT ISMLEKKKKG TPEDLIKHAL ENFKALDIKQ LIQETSLDQV EVEGILTSRV
EDEIIVILPN KRFTLSSLLI KVEEQLVENL KEYHDANPMR LGRDKAELVQ ILTNEFPKEL
IDFHLNMMLD KNMIKKEGQF ISLTVFKSHL PDNWKKRMKQ VIRNIENDQL AVGKWEEYVK
DKPFSKADAD ELKNYLIQTG QAYRLTDDFL IHKRSLDKAI EQLKSNTETT FTLKDAKEVL
GVSRKYLIPI LELLDQLRLT RRKESEREWV
//
