ID A0A917I336_9HYPH Unreviewed; 647 AA.
AC A0A917I336;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:GGH07780.1};
GN ORFNames=GCM10007036_02860 {ECO:0000313|EMBL:GGH07780.1};
OS Alsobacter metallidurans.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Alsobacteraceae; Alsobacter.
OX NCBI_TaxID=340221 {ECO:0000313|EMBL:GGH07780.1, ECO:0000313|Proteomes:UP000603912};
RN [1] {ECO:0000313|EMBL:GGH07780.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.12214 {ECO:0000313|EMBL:GGH07780.1};
RX PubMed=25193709;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Walter F., Albersmeier A., Kalinowski J., Ruckert C.;
RT "Complete genome sequence of Corynebacterium casei LMG S-19264T (=DSM
RT 44701T), isolated from a smear-ripened cheese.";
RL Int. J. Syst. Evol. Microbiol. 189:76-77(2014).
RN [2] {ECO:0000313|EMBL:GGH07780.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.12214 {ECO:0000313|EMBL:GGH07780.1};
RA Sun Q., Zhou Y.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GGH07780.1}.
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DR EMBL; BMES01000001; GGH07780.1; -; Genomic_DNA.
DR RefSeq; WP_188515955.1; NZ_BMES01000001.1.
DR AlphaFoldDB; A0A917I336; -.
DR Proteomes; UP000603912; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000603912}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 647 AA; 69727 MW; 38A6D2A36A42AF6F CRC64;
MIVGTAGHID HGKSSLVRAI TGVDPDRLKE EKARGITIDL GFAYWPQPDG SAIGFVDVPG
HERFVHTMLA GATGIDLVLL VVAADDGVMP QTREHLAIMD LLGLRRGVVA LTKVDLVDAA
RLATVRAEVE AALHGTALAG SPIAPVSTVT GEGLPELEAL LAAEANVTTL RREAGLFRLL
VDRCFTLSGA GTVVTGSVVA GSVAVGDEVV VSPSGLTARV RFIHAQNRPA ERGRAGDRCA
LNLAGPGVAK DAIRRGDVVM DPRLHAPTQR LDAELRVLPT EPKGVGLWMP VWLHLGSAEV
AARVVPLGDG AIRPGQTGRV QLVLDSPIAA VAHDRFVIRD TSATRTIGGG RVLDLRAPER
RRRTPERLAQ LDALAHPRVE DALAALVRTA PFHVPLGAFA RDHGLAPTDL VRIADAQALI
RVPVGDDAVA MDPAIWLALK QNMLAALAAW HESNPDLVGV GLERLRLQLE PRLPAPLFRA
ILQALARPPA SAPEIALQGA WVRLAGHEVR LSPEDEALWA RIRPLIEGEE RFRPPRVRDI
ASLLDVEEPR IRRTFKLTGR RGEVDEVAHD HFFLRSTVAE MIAIATQLAA GAPKGEFTAA
QFRDRLDNGR KVAIQILEFF DRHGVTMRRG DLRRINRHRL DLFGAAA
//
