ID   A0A919WFU9_9BACI        Unreviewed;       147 AA.
AC   A0A919WFU9;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   18-JUN-2025, entry version 8.
DE   RecName: Full=Hut operon positive regulatory protein {ECO:0000256|ARBA:ARBA00019377, ECO:0000256|HAMAP-Rule:MF_00779};
GN   Name=hutP {ECO:0000256|HAMAP-Rule:MF_00779,
GN   ECO:0000313|EMBL:GIN60946.1};
GN   ORFNames=J27TS8_09390 {ECO:0000313|EMBL:GIN60946.1};
OS   Robertmurraya siralis.
OC   Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC   Robertmurraya.
OX   NCBI_TaxID=77777 {ECO:0000313|EMBL:GIN60946.1, ECO:0000313|Proteomes:UP000682111};
RN   [1] {ECO:0000313|EMBL:GIN60946.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=J27TS8 {ECO:0000313|EMBL:GIN60946.1};
RA   Okamoto M., Kumagai M., Kanamori H., Takamatsu D.;
RT   "Antimicrobial resistance genes in bacteria isolated from Japanese honey,
RT   and their potential for conferring macrolide and lincosamide resistance in
RT   the American foulbrood pathogen Paenibacillus larvae.";
RL   Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antiterminator that binds to cis-acting regulatory sequences
CC       on the mRNA in the presence of histidine, thereby suppressing
CC       transcription termination and activating the hut operon for histidine
CC       utilization. {ECO:0000256|ARBA:ARBA00002945, ECO:0000256|HAMAP-
CC       Rule:MF_00779}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000256|ARBA:ARBA00011643,
CC       ECO:0000256|HAMAP-Rule:MF_00779}.
CC   -!- SIMILARITY: Belongs to the HutP family. {ECO:0000256|ARBA:ARBA00009992,
CC       ECO:0000256|HAMAP-Rule:MF_00779}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GIN60946.1}.
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DR   EMBL; BORC01000001; GIN60946.1; -; Genomic_DNA.
DR   OrthoDB; 2388985at2; -.
DR   Proteomes; UP000682111; Unassembled WGS sequence.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006547; P:L-histidine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-UniRule.
DR   CDD; cd11640; HutP; 1.
DR   Gene3D; 3.40.1510.10; Hut operon regulatory protein HutP; 1.
DR   HAMAP; MF_00779; HutP; 1.
DR   InterPro; IPR015111; Regulatory_HutP.
DR   InterPro; IPR023552; Regulatory_HutP_bacillales.
DR   InterPro; IPR036482; Regulatory_HutP_sf.
DR   NCBIfam; NF002838; PRK03065.1; 1.
DR   Pfam; PF09021; HutP; 1.
DR   SUPFAM; SSF111064; Hut operon positive regulatory protein HutP; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|HAMAP-Rule:MF_00779};
KW   Histidine metabolism {ECO:0000256|ARBA:ARBA00022808, ECO:0000256|HAMAP-
KW   Rule:MF_00779}; Reference proteome {ECO:0000313|Proteomes:UP000682111};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_00779};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00779};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00779}.
SQ   SEQUENCE   147 AA;  16213 MW;  2D41E6015A01DAA5 CRC64;
     MALKKEQRIG RHATLLLLTD DHRELSQQTE QIGWKSCLGK VGSMESQKVV AAIEVAAKQQ
     GVISQELYRE THALYHAIME ALHGITRGQM QLGSVMRTVG LRFAVVRGNP YEDEAEGEWI
     AVAIYGTIGA PVRGLEHETL GLGINHI
//