ID A0A921YTT8_MANSE Unreviewed; 245 AA.
AC A0A921YTT8;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Enhancer of split mbeta protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=O3G_MSEX003733 {ECO:0000313|EMBL:KAG6445065.1};
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130 {ECO:0000313|EMBL:KAG6445065.1, ECO:0000313|Proteomes:UP000791440};
RN [1] {ECO:0000313|EMBL:KAG6445065.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27522922;
RA Kanost M.R., Arrese E.L., Cao X., Chen Y.R., Chellapilla S.,
RA Goldsmith M.R., Grosse-Wilde E., Heckel D.G., Herndon N., Jiang H.,
RA Papanicolaou A., Qu J., Soulages J.L., Vogel H., Walters J.,
RA Waterhouse R.M., Ahn S.J., Almeida F.C., An C., Aqrawi P.,
RA Bretschneider A., Bryant W.B., Bucks S., Chao H., Chevignon G.,
RA Christen J.M., Clarke D.F., Dittmer N.T., Ferguson L.C.F., Garavelou S.,
RA Gordon K.H.J., Gunaratna R.T., Han Y., Hauser F., He Y., Heidel-Fischer H.,
RA Hirsh A., Hu Y., Jiang H., Kalra D., Klinner C., Konig C., Kovar C.,
RA Kroll A.R., Kuwar S.S., Lee S.L., Lehman R., Li K., Li Z., Liang H.,
RA Lovelace S., Lu Z., Mansfield J.H., McCulloch K.J., Mathew T., Morton B.,
RA Muzny D.M., Neunemann D., Ongeri F., Pauchet Y., Pu L.L., Pyrousis I.,
RA Rao X.J., Redding A., Roesel C., Sanchez-Gracia A., Schaack S., Shukla A.,
RA Tetreau G., Wang Y., Xiong G.H., Traut W., Walsh T.K., Worley K.C., Wu D.,
RA Wu W., Wu Y.Q., Zhang X., Zou Z., Zucker H., Briscoe A.D., Burmester T.,
RA Clem R.J., Feyereisen R., Grimmelikhuijzen C.J.P., Hamodrakas S.J.,
RA Hansson B.S., Huguet E., Jermiin L.S., Lan Q., Lehman H.K., Lorenzen M.,
RA Merzendorfer H., Michalopoulos I., Morton D.B., Muthukrishnan S.,
RA Oakeshott J.G., Palmer W., Park Y., Passarelli A.L., Rozas J.,
RA Schwartz L.M., Smith W., Southgate A., Vilcinskas A., Vogt R., Wang P.,
RA Werren J., Yu X.Q., Zhou J.J., Brown S.J., Scherer S.E., Richards S.,
RA Blissard G.W.;
RT "Multifaceted biological insights from a draft genome sequence of the
RT tobacco hornworm moth, Manduca sexta.";
RL Insect Biochem. Mol. Biol. 76:118-147(2016).
RN [2] {ECO:0000313|EMBL:KAG6445065.1}
RP NUCLEOTIDE SEQUENCE.
RA Kanost M.;
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG6445065.1}.
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DR EMBL; JH668316; KAG6445065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A921YTT8; -.
DR OrthoDB; 6085656at2759; -.
DR Proteomes; UP000791440; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19741; bHLH-O_ESMB_like; 1.
DR FunFam; 4.10.280.10:FF:000072; enhancer of split mgamma protein-like; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000791440};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 32..89
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 107..150
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..191
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 27503 MW; D1AA7B4F42CB4A00 CRC64;
MILPARTMSP HGVFHPPHEQ PEDEPVSRTY QYRKVMKPML ERKRRARINR CLDELKDLMV
TALQAEGENV SKLEKADILE LTVRHLHNLK RRGQLVLKPE MSYAERFRAG FTQCATEVSQ
FIANATLAAN AMQRQGPVDP QAGARLLQHL SNCIRRLEAP QVVQPQPITP NGVARPTPLQ
PIAPAPQPQQ PPQIQRITPE RGLKRPCEGP TDAEAVLAKR AYAPPSPPHS PASESDSAQS
MWRPW
//
