ID A0A922CN38_MANSE Unreviewed; 443 AA.
AC A0A922CN38;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN ORFNames=O3G_MSEX007986 {ECO:0000313|EMBL:KAG6453155.1};
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130 {ECO:0000313|EMBL:KAG6453155.1, ECO:0000313|Proteomes:UP000791440};
RN [1] {ECO:0000313|EMBL:KAG6453155.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27522922;
RA Kanost M.R., Arrese E.L., Cao X., Chen Y.R., Chellapilla S.,
RA Goldsmith M.R., Grosse-Wilde E., Heckel D.G., Herndon N., Jiang H.,
RA Papanicolaou A., Qu J., Soulages J.L., Vogel H., Walters J.,
RA Waterhouse R.M., Ahn S.J., Almeida F.C., An C., Aqrawi P.,
RA Bretschneider A., Bryant W.B., Bucks S., Chao H., Chevignon G.,
RA Christen J.M., Clarke D.F., Dittmer N.T., Ferguson L.C.F., Garavelou S.,
RA Gordon K.H.J., Gunaratna R.T., Han Y., Hauser F., He Y., Heidel-Fischer H.,
RA Hirsh A., Hu Y., Jiang H., Kalra D., Klinner C., Konig C., Kovar C.,
RA Kroll A.R., Kuwar S.S., Lee S.L., Lehman R., Li K., Li Z., Liang H.,
RA Lovelace S., Lu Z., Mansfield J.H., McCulloch K.J., Mathew T., Morton B.,
RA Muzny D.M., Neunemann D., Ongeri F., Pauchet Y., Pu L.L., Pyrousis I.,
RA Rao X.J., Redding A., Roesel C., Sanchez-Gracia A., Schaack S., Shukla A.,
RA Tetreau G., Wang Y., Xiong G.H., Traut W., Walsh T.K., Worley K.C., Wu D.,
RA Wu W., Wu Y.Q., Zhang X., Zou Z., Zucker H., Briscoe A.D., Burmester T.,
RA Clem R.J., Feyereisen R., Grimmelikhuijzen C.J.P., Hamodrakas S.J.,
RA Hansson B.S., Huguet E., Jermiin L.S., Lan Q., Lehman H.K., Lorenzen M.,
RA Merzendorfer H., Michalopoulos I., Morton D.B., Muthukrishnan S.,
RA Oakeshott J.G., Palmer W., Park Y., Passarelli A.L., Rozas J.,
RA Schwartz L.M., Smith W., Southgate A., Vilcinskas A., Vogt R., Wang P.,
RA Werren J., Yu X.Q., Zhou J.J., Brown S.J., Scherer S.E., Richards S.,
RA Blissard G.W.;
RT "Multifaceted biological insights from a draft genome sequence of the
RT tobacco hornworm moth, Manduca sexta.";
RL Insect Biochem. Mol. Biol. 76:118-147(2016).
RN [2] {ECO:0000313|EMBL:KAG6453155.1}
RP NUCLEOTIDE SEQUENCE.
RA Kanost M.;
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG6453155.1}.
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DR EMBL; JH668437; KAG6453155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A922CN38; -.
DR Proteomes; UP000791440; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000791440}.
FT DOMAIN 18..131
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 301..412
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 125..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..146
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..302
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 45606 MW; 6960C6D3B08EEA9F CRC64;
MSATALFGNT SGLGGSSGGN KHLVEFRAGR MTLKGRMVHP DKRKGLLYVY QGEDSLMHFC
WKDRTTGEVE DDLLIFPDDC EFVRVNECTT GRVYVLKFKS LSKKYFFWMQ EPKSDKDDDY
CRRINEALNN PPTSGGRGGG GSGGQDGELQ NLLNNMSQQQ LMQLFGGVGQ IGGLSSLLGT
MGNNSSNSGS RPSAGSGTRG GGAARAPSRA RDAATPAPAA APAAAAAATP APATAPAAAA
TAATPASATA PVAADTDSPA QPRSGQIFLS DLQRYFSGLG NAPPEGDDSS AGATAGTESS
SADRAGAVTL SSMLASPEVI SVATTPENVA QLTPLLPPAP TGVAQDDVRT TLLSPQFAQA
ANLFSSALST GEMGPVMTQF GLPAEVAAAA STGDMGVFFK ALENTSGESD SSKSKEGDDK
KKEDKPKGSN NDKKDDDAEM SLD
//
