ID A0A923E914_CLOTT Unreviewed; 568 AA.
AC A0A923E914;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MBC2397341.1};
GN ORFNames=HGG79_06060 {ECO:0000313|EMBL:MBC2397341.1};
OS Clostridium tetanomorphum.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1553 {ECO:0000313|EMBL:MBC2397341.1, ECO:0000313|Proteomes:UP000563151};
RN [1] {ECO:0000313|EMBL:MBC2397341.1, ECO:0000313|Proteomes:UP000563151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DJ011 {ECO:0000313|EMBL:MBC2397341.1,
RC ECO:0000313|Proteomes:UP000563151};
RA Brown S.;
RT "Genomic insights into acetone-butanol-ethanol (ABE) fermentation by
RT sequencing solventogenic clostridia strains.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBC2397341.1}.
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DR EMBL; JAAZWO010000005; MBC2397341.1; -; Genomic_DNA.
DR RefSeq; WP_035144377.1; NZ_JAAZWO010000005.1.
DR AlphaFoldDB; A0A923E914; -.
DR Proteomes; UP000563151; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBC2397341.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000563151}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 568 AA; 65207 MW; 9BD5801D8C30D4F7 CRC64;
MRHIVIGTAG HIDHGKTSLI KALTEQDTDR LKEEKKRGIS INLGFAYLDL PCGKRAGIID
VPGHEKFIKN MLAGISSIDL VLMVIAADEG VMPQTREHLQ ILKLLDIKKG IVVLTKTDLV
QKEWINIVKD EIKKEIQESF LQESKIYEVS CVTKKGIEEL IKALDDISEE LEEENIKEDF
RMSVDRVFTV SGFGTVVTGT VLNGMVNQGE TIEIYPSKIN CKVRGIQVHE QKVNFAKIGQ
RTALNLSNVK VKEIKRGDVI SSINAMESSI IIDCRLHYLK ENNKPLKNRQ RVRLHHGTSE
ILCRVVILDK EDIRPGESVY VQLKLESPIA CKSEDRFIIR NYSPMYTIGG GIIIDPVSKK
AKRFDKDYIN ELKIKENRNV EEILENVIKK FTEQVPDKNL IQKHLDIDDE VLKKEINKLK
DKGKIIEICI DNNIRYIHNI YWKEKAKGLI EIYNEAGFSP PKYEEILEKE NNKKIFNIIY
YSLIKNKDII IISEDIVLSC SNYYKAKRII IDTINKNGNI TLAEFRDILN TSRKYALAII
EHFDSIKLTK RIGDKRILYS VDLKETFV
//
