ID A0A923I137_9BURK Unreviewed; 467 AA.
AC A0A923I137;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN ORFNames=H8K47_10125 {ECO:0000313|EMBL:MBC3935716.1};
OS Undibacterium rugosum.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Oxalobacteraceae; Undibacterium.
OX NCBI_TaxID=2762291 {ECO:0000313|EMBL:MBC3935716.1, ECO:0000313|Proteomes:UP000612361};
RN [1] {ECO:0000313|EMBL:MBC3935716.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CY7W {ECO:0000313|EMBL:MBC3935716.1};
RA Lu H.;
RT "Novel species isolated from subtropical streams in China.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-aspartate + ATP = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00047872,
CC ECO:0000256|RuleBase:RU003448};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004766, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC {ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5. {ECO:0000256|RuleBase:RU004249}.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
CC {ECO:0000256|ARBA:ARBA00010122, ECO:0000256|RuleBase:RU003448}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBC3935716.1}.
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DR EMBL; JACOGG010000009; MBC3935716.1; -; Genomic_DNA.
DR RefSeq; WP_186881284.1; NZ_JACOGG010000009.1.
DR Proteomes; UP000612361; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:InterPro.
DR GO; GO:0009090; P:homoserine biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR CDD; cd04868; ACT_AK-like; 1.
DR Gene3D; 3.30.70.260; -; 2.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR NCBIfam; TIGR00657; asp_kinases; 1.
DR PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR PANTHER; PTHR21499:SF59; ASPARTOKINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF13840; ACT_7; 1.
DR PIRSF; PIRSF000726; Asp_kin; 1.
DR SUPFAM; SSF55021; ACT-like; 2.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003448};
KW Reference proteome {ECO:0000313|Proteomes:UP000612361};
KW Transferase {ECO:0000256|RuleBase:RU003448}.
FT DOMAIN 2..289
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
FT DOMAIN 319..382
FT /note="CASTOR ACT"
FT /evidence="ECO:0000259|Pfam:PF13840"
SQ SEQUENCE 467 AA; 49452 MW; 3C545F314B231B95 CRC64;
MKKIVVKFGG SNLRQPQDID RVVNVVQAYQ RPLVLVVSAF YGITNALIAC VQAAREGAGT
KAALAESQNY TQTLRALKKQ ILEANISDPE HRARTEQALG ARLDQLDRYL TGIHCIGDVP
TFVNDAILSY GERLSSLLLT EVLLSRGIAA REALPEDIGL ITDGVFGNSA CDFAASTASV
SAALADDVVF VVPGFYGIDA QGKTTLFGRG GSDYSAASIA ACISAESLDV WKDVDGFLSA
DPGAVSAPRS ISQLNYLEAA ELSYFGAKIL HPRTVEPLFD RDIPIRILNI TQPERGLQPY
TIIDAQRHVT RDVVKSVSST DDVAILKLHG PGVGFKAGIL AQVTNTLDQH GINIKSVLTA
QTAINILLAR DHLDAAYAAL SEHHLAGVVN VSCDDAVAIV AVVGDGVLDA SDVGSAIASR
ALSAALAGGV RVRLAAAGAS EVAAYMLVQQ EDRKLALRLV HEEFFGK
//
