ID   A0A923LBZ6_9FIRM        Unreviewed;       661 AA.
AC   A0A923LBZ6;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   28-JAN-2026, entry version 12.
DE   SubName: Full=CoB--CoM heterodisulfide reductase iron-sulfur subunit A family protein {ECO:0000313|EMBL:MBC5659733.1};
GN   ORFNames=H8S44_08115 {ECO:0000313|EMBL:MBC5659733.1};
OS   Anaerosacchariphilus hominis.
OC   Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
OC   Lachnospiraceae; Anaerosacchariphilus.
OX   NCBI_TaxID=2763017 {ECO:0000313|EMBL:MBC5659733.1, ECO:0000313|Proteomes:UP000649345};
RN   [1] {ECO:0000313|EMBL:MBC5659733.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NSJ-68 {ECO:0000313|EMBL:MBC5659733.1};
RA   Liu C., Sun Q.;
RT   "Genome public.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the HdrA family.
CC       {ECO:0000256|ARBA:ARBA00006561}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBC5659733.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JACOOR010000004; MBC5659733.1; -; Genomic_DNA.
DR   RefSeq; WP_186872040.1; NZ_JACOOR010000004.1.
DR   AlphaFoldDB; A0A923LBZ6; -.
DR   Proteomes; UP000649345; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 2.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039650; HdrA-like.
DR   PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR   PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 3.
DR   PROSITE; PS51379; 4FE4S_FER_2; 4.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022827};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000649345}.
FT   DOMAIN          234..265
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          282..316
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          577..606
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          618..647
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   661 AA;  71976 MW;  B8C3CADDBB12446D CRC64;
     MQRIGVFVCH CGTNIAATVD VKRVVEAAAK EPGVVHAEDY QYMCSEAGQL KIREAIEQKH
     LTGIVVCSCS PRMHENTFRQ AAKRAGINPY MVEIANIREH CSWIHKDIEE ATEKAVILAR
     AAIAKVMLNA PLTPGTSQVV KRALVIGGGI AGIQTALDIA DAGYEVDIVE KTPSIGGRMS
     QLDKTFPTLD CSACILTPKM VEAAAHEKIT IYTYSEVEKV SGFVGDFHVD IRKKARSVDM
     SKCTGCGVCQ EKCPSRKTPN EFNRGLNTRS AIYTPFAQAI PNVPVIDREH CTKFKTGKCG
     VCAKVCQAGA IDYDQQDEII TVDYGAIVVA TGFDTIKLDK YDEYAYNQSP DVITSLELER
     IMNAAGPTKG HLERMSDHKP PKSMVFIQCV GSRCADKRGK SYCSKICCMY TAKHAMLIRD
     KYPDVDVTVF YIDVRTPGKN FDEFYRRAVE EYGVHYIKGQ VGKVAPQGDK LLVQAADLLD
     NKQIRMETDM VVLATAIEPN PDVRKIATML TASIDTNNFL TESHAKLRPV ESPTAGIFLS
     GVCQGPKDIP ETVAQAGAAA VKVVGLLAKD HLVTNPCTAK ADPIFCNGCS TCEKVCPYGA
     ISYEDQLVND HGIRETRRVA VVNSALCQGC GACTVACPSG AMDLQGFSNR QILAEVDAIC
     R
//