UniProt: A0A923NCH0

Database: UniProt
Entry: A0A923NCH0_9BACT

LinkDB:  A0A923NCH0_9BACT 
Original site:  A0A923NCH0_9BACT

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Ontology (3)   
   GO (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
All databases (18)   

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ID   A0A923NCH0_9BACT        Unreviewed;       451 AA.
AC   A0A923NCH0;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   02-APR-2025, entry version 6.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   Name=mgtE {ECO:0000313|EMBL:MBC5994400.1};
GN   ORFNames=H8S84_16245 {ECO:0000313|EMBL:MBC5994400.1};
OS   Pontibacter cellulosilyticus.
OC   Bacteria; Pseudomonadati; Bacteroidota; Cytophagia; Cytophagales;
OC   Hymenobacteraceae; Pontibacter.
OX   NCBI_TaxID=1720253 {ECO:0000313|EMBL:MBC5994400.1, ECO:0000313|Proteomes:UP000603640};
RN   [1] {ECO:0000313|EMBL:MBC5994400.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SD6 {ECO:0000313|EMBL:MBC5994400.1};
RA   Kang M.;
RT   "Pontibacter sp. SD6 16S ribosomal RNA gene Genome sequencing and
RT   assembly.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBC5994400.1}.
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DR   EMBL; JACRVF010000005; MBC5994400.1; -; Genomic_DNA.
DR   RefSeq; WP_187068429.1; NZ_JACRVF010000005.1.
DR   Proteomes; UP000603640; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Reference proteome {ECO:0000313|Proteomes:UP000603640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        313..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        422..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          141..204
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          205..261
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   451 AA;  50750 MW;  7D920C1676D3D3C1 CRC64;
     MQQLEITRDF IEQVEQAIER KDSEFILSTM GDMHPADITT VLYELDANES KYVMDLLPPE
     IGAEILSDLD YDIREDFLDY FTSAEIARYI NLMHSDDAVD ILNEQSVQTR EEVIALIENE
     EKAKDILDLL HYEEDCAGGL MAKELIKVNL NWRVRQCIEE IRRQAEDVSR IYTVYVVDNR
     DILVGRVSVK ALLLSRDDKL VKDIYSEDVI SIESFRDENE VVTVMQKYDL EAIPVVNIQG
     RLLGRITIDD VVDVMQEQAE LSRQLMTGIS ENVEEDDSVF RISRSRLPWL IIGMVGGLLA
     AHFMGFFEND IAILPALALF VPLITATGGN VGIQSSSIII QTLSSNAVMF ENFAQRIFKM
     ILVALLNALI ISILVFCFTY LFRNDFTLSL VVSLALFSVV MLASLMGTVT PMVLDKFGIN
     PAVAAGPFIT TANDLLGLTI YFGVAHLLYS L
//

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