ID A0A923RJ15_9BACI Unreviewed; 589 AA.
AC A0A923RJ15;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 14.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=H8S33_09820 {ECO:0000313|EMBL:MBC5637103.1};
OS Ornithinibacillus hominis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Ornithinibacillus.
OX NCBI_TaxID=2763055 {ECO:0000313|EMBL:MBC5637103.1, ECO:0000313|Proteomes:UP000637359};
RN [1] {ECO:0000313|EMBL:MBC5637103.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BX22 {ECO:0000313|EMBL:MBC5637103.1};
RA Liu C., Sun Q.;
RT "Genome public.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC raft {ECO:0000256|ARBA:ARBA00004314}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004314}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBC5637103.1}.
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DR EMBL; JACOOL010000006; MBC5637103.1; -; Genomic_DNA.
DR RefSeq; WP_186869814.1; NZ_JACOOL010000006.1.
DR Proteomes; UP000637359; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:TreeGrafter.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IEA:TreeGrafter.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR FunFam; 3.30.565.10:FF:000023; PAS domain-containing sensor histidine kinase; 1.
DR FunFam; 1.10.287.130:FF:000001; Two-component sensor histidine kinase; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR041328; HisK_sensor.
DR InterPro; IPR052545; Light-responsive_reg.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR42878:SF3; HISTIDINE PROTEIN KINASE SAES; 1.
DR PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF18698; HisK_sensor; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000637359};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 189..241
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 367..587
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 589 AA; 66765 MW; 38336A44F9B26D7D CRC64;
MFWRSVVGKL AVTILLLVSF VLFVLTIFLL EFFENFHIQE AEEALLQTAT KVSVMVENHE
DKSLIYETTE RVKDPSSKVI ILFSEGDYWS SETDDIHLSS LRDEWLIEQS DVAGIMADDD
NNNDEIEVSE DEPGIMLVGK TVPNTDDVVL VYQSLAIVDR TKAETTKIIL GAAAVAIILT
TIFAFFLSTR ITSPLIKMRE AAFDLTRGEF NTKVPILTHD EIGELAMAFN HMGRQLKFHI
NALRQEKEQL SSIVNSMADG VITLSRSGEI IATNQPAERF IEDWYFEKNL QSDTESRKLP
KELLDTLQQV IEGEKEVIEE ITLQGRTWVM IMTPLYDQAY IRGAVAVIRD MTEERRLDKL
RKDFIANVSH ELRTPISMLQ GYSEAIVDDI AETKEEKNEL AQIIYEESLR LSRLVNELLD
MASMEAGHLT LKKEKVDITP YIERIFRKFQ GIAAENQIEM SLAKDIQEAQ AYFDPDRIEQ
VFTNLIDNAI RHTSEGGFVK VSVTNDDNGL SVSVEDSGSG IPEEDLPFVF ERFYKADKSR
TRNKHVKGTG LGLSIAKNIV KSHRGTITVK SKLDIGTTFN FMIPKEEDI
//
