ID A0A924CQE1_9CYAN Unreviewed; 457 AA.
AC A0A924CQE1;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=Proton extrusion protein PxcA {ECO:0000256|HAMAP-Rule:MF_01308};
GN Name=pxcA {ECO:0000256|HAMAP-Rule:MF_01308};
GN ORFNames=H7237_07420 {ECO:0000313|EMBL:MBC7516241.1};
OS Leptolyngbyaceae cyanobacterium LF-bin-369.
OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Leptolyngbyales;
OC Leptolyngbyaceae.
OX NCBI_TaxID=2804781 {ECO:0000313|EMBL:MBC7516241.1, ECO:0000313|Proteomes:UP000635701};
RN [1] {ECO:0000313|EMBL:MBC7516241.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LF-bin-369 {ECO:0000313|EMBL:MBC7516241.1};
RA Zeng Y.;
RT "Metagenome-assembled genomes from the Lille Firn glacier at the Villum
RT Research Station in northeast Greenland.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for H(+) efflux immediately after light irradiation
CC to form a rapid H(+) concentration gradient across the thylakoid
CC membranes. Together with PxcL, contributes to transient H(+) uptake
CC following dark to light transition. {ECO:0000256|HAMAP-Rule:MF_01308}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01308}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01308}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CemA family. {ECO:0000256|HAMAP-
CC Rule:MF_01308}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBC7516241.1}.
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DR EMBL; JACMPV010000245; MBC7516241.1; -; Genomic_DNA.
DR Proteomes; UP000635701; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01308; CemA_PxcA; 1.
DR InterPro; IPR004282; CemA.
DR PANTHER; PTHR33650:SF2; CHLOROPLAST ENVELOPE MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR33650; CHLOROPLAST ENVELOPE MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF03040; CemA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01308};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01308};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01308};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01308}.
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
FT TRANSMEM 416..437
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
SQ SEQUENCE 457 AA; 52023 MW; 7993DBDD967A0A65 CRC64;
MKTSFWSKVT GYVRHAENWY LTTPDRALDE AYDAALMIQA IENEHFKGLK ILPQNSNNLG
QEAFIYFDQE REKHLKLLKL RLSEFRLSRS TVDATNPKES RLRSDRALTD DRSTAILEKL
KFIDQVIARY PSQALALVQS TAVQTVPKTL TSYTPKDAER RSDFEVANRK PAATKLGSLE
SITDKTGVLP RSILGTINRL KRDLNPAGEV EAIQDFQTKR MRTKIAIRFM LILVAVPLLM
QISIRNFALS DRLIPGHLIS QRFAVVNPAS IFINGEMSEE ALKELSQFEE KIKFENILKE
AIGQELVTPE IREEKIRDKV DEIAKDYSRR SSSAVKNWIS DLAGVVAFVF ILTKGKAEMQ
ILKDFIDEVS YGLSDSAKAF IIILFTDIFV GFHSPHGWEV LLEGVAQHFG LAANRSYISL
FIATFPVILD TIFKYWIFRY LNRISPSAVA TYKDMNE
//
