ID A0A924IA58_9BACT Unreviewed; 570 AA.
AC A0A924IA58;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=H7308_02705 {ECO:0000313|EMBL:MBC7526436.1};
OS Chthonomonadaceae bacterium.
OC Bacteria; Bacillati; Armatimonadota; Chthonomonadia; Chthonomonadales;
OC Chthonomonadaceae.
OX NCBI_TaxID=2739509 {ECO:0000313|EMBL:MBC7526436.1, ECO:0000313|Proteomes:UP000601118};
RN [1] {ECO:0000313|EMBL:MBC7526436.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FL-bin-356 {ECO:0000313|EMBL:MBC7526436.1};
RA Zeng Y.;
RT "Metagenome-assembled genomes from the Lille Firn glacier at the Villum
RT Research Station in northeast Greenland.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|ARBA:ARBA00038437}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBC7526436.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JACMPS010000088; MBC7526436.1; -; Genomic_DNA.
DR Proteomes; UP000601118; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd12252; RRM_DbpA; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR FunFam; 3.40.50.300:FF:000108; ATP-dependent RNA helicase RhlE; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005580; DbpA/CsdA_RNA-bd_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR050079; DEAD_box_RNA_helicase.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF1; ATP-DEPENDENT RNA HELICASE DBPA; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF03880; DbpA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF25399; DeaD_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:MBC7526436.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 43..71
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 74..244
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 255..416
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 43..71
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 63071 MW; 0A473425DE388715 CRC64;
MAKKEKSVAT VEERPESAAL TTPVAEPEID LEIETPLASG LPAAFAALGL GEPLLRAIAE
SGFTQPTPIQ SEAIPFFLTG RDLIGQAQTG TGKTAAFALP LAQLIDPDKR KPQAIVLLPT
RELCLQVSAE TRHLSKFCRI RVVAVYGGQP IDRQFRALEA GAHIVVGTPG RVLDHIRRGT
LDLSDIQYVA LDEADEMLQM GFIEDVEEIL KSAPKQRQTA LFSATMPPRI AALANETMKN
PYHIKIQPKE RTVARITQTY YEVPNSRKQE ALLRILDMEE PKSAIIFCKT KKDVDDLGEA
LQNKGFNAET LHGDMNQTLR DRVMGRFRSG KAEILVATDV AARGLDIDQV THVFNFDLPW
DTESYIHRIG RTGRAGRSGD AITLVTPRDR HQIKMLEKQI KAPIGQAQVP TPADIARRHR
ERFQKEVEAA LELGDFDREA LIVEAITEKT DWTTGEIAAA AMNLLWKSRR LTDFDLDAAR
ETDARAEVGM VRIFLQIGRF DNVRPGDIVG AIANEAGLSG KSVGAIEIFD RSSYVEVPER
DASRVISALN NTKLRGRKVR ADVARPKDDR
//
