ID   A0A926XJ77_9CYAN        Unreviewed;      1315 AA.
AC   A0A926XJ77;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   02-APR-2025, entry version 9.
DE   SubName: Full=HEAT repeat domain-containing protein {ECO:0000313|EMBL:MBD2576216.1};
GN   ORFNames=H6G50_00745 {ECO:0000313|EMBL:MBD2576216.1};
OS   Oscillatoria sp. FACHB-1406.
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Oscillatoriaceae; Oscillatoria.
OX   NCBI_TaxID=2692846 {ECO:0000313|EMBL:MBD2576216.1, ECO:0000313|Proteomes:UP000634205};
RN   [1] {ECO:0000313|EMBL:MBD2576216.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FACHB-1406 {ECO:0000313|EMBL:MBD2576216.1};
RX   PubMed=32943748;
RA   Chen M.Y., Teng W.K., Zhao L., Hu C.X., Zhou Y.K., Han B.P., Song L.R.,
RA   Shu W.S.;
RT   "Comparative genomics reveals insights into cyanobacterial evolution and
RT   habitat adaptation.";
RL   ISME J. 0:0-0(2020).
RN   [2] {ECO:0000313|EMBL:MBD2576216.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FACHB-1406 {ECO:0000313|EMBL:MBD2576216.1};
RA   Chen M., Teng W., Zhao L., Hu C., Zhou Y., Han B., Song L., Shu W.;
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-
CC       lysine intermediate produced by deoxyhypusine synthase/DHPS on a
CC       critical lysine of the eukaryotic translation initiation factor 5A/eIF-
CC       5A. This is the second step of the post-translational modification of
CC       that lysine into an unusual amino acid residue named hypusine.
CC       Hypusination is unique to mature eIF-5A factor and is essential for its
CC       function. {ECO:0000256|ARBA:ARBA00045876}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBD2576216.1}.
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DR   EMBL; JACJSM010000001; MBD2576216.1; -; Genomic_DNA.
DR   RefSeq; WP_190712304.1; NZ_JACJSM010000001.1.
DR   Proteomes; UP000634205; Unassembled WGS sequence.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:TreeGrafter.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 8.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   PANTHER; PTHR12697:SF5; DEOXYHYPUSINE HYDROXYLASE; 1.
DR   PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13646; HEAT_2; 4.
DR   Pfam; PF03130; HEAT_PBS; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   SMART; SM00567; EZ_HEAT; 20.
DR   SUPFAM; SSF48371; ARM repeat; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 4.
PE   4: Predicted;
KW   Antenna complex {ECO:0000256|ARBA:ARBA00022549};
KW   Phycobilisome {ECO:0000256|ARBA:ARBA00022738};
KW   Reference proteome {ECO:0000313|Proteomes:UP000634205};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          95..237
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|Pfam:PF05729"
SQ   SEQUENCE   1315 AA;  145138 MW;  45A44616739742BF CRC64;
     MTDAPCEAAR SPDFQPYLQA IRQRYERWWE VYSVTDVRGR ENCPPSAPPY GKNSSSPFDF
     GLTVQVVTPE EKRPQQPLPV LERLRKYVFD EKTRHLLLVG RPGSGKSTAL ARLLLEESNA
     TSGVIPVLVE LRYWQTSIEA LILDFFGQHG LKLNETQLET LLVEKRFLLL MDGINELSSE
     TARSQLNTFR QTYRQLPIIF TTRDLSLGGD FGIEKKLEMQ RLTEPQIQAF VRAYLSEPGE
     ELLRQSQGKL RQFGETPLLL WMLCEVFQQS PQAQLPRNLG GIFQVFARSY ENSSVRKHEV
     APLKGDTKPL SERKLWAKAL EHLAGLMVRG KNSVELEVTI ERQVAERELE GLFQGEPFPP
     KTARDCLDDL LKYHLLQMKV EDKIEFLHQL IQEYYAAEAL LARLPELSDA ELKRDYLNYL
     KWTEPVALML GLVGDETQAL RVVRLALEVD WRLGARLAGE VKRDFQEQTV GIVTALDVPQ
     GLKWELWVET RSDVAVSELV NAGEDESSWV RQRAAEVLGK LGSEAAIPGL LSAVRGSVVE
     ALGKLGSEAA IPRLLSALED EDSWVRKSAV EALGKLGLEA AIPGLLSALE DEDSWVRESA
     VKALGKLGSE AAIPGLLWTL EDEDYRVRES AVKALGKLGS EAAIPGLLWA LEYEDSDGRE
     STVETLGKLG SEAAIPGLLW TLEDEDYRVR ESAVKALGKL GSEAAIPGLL WALENESSLV
     RESAVKALGK LGSEAAIPGL LFALEDESSR VRESAVEAIG KLGSEEVIPG LLSALKDEDD
     LVSMRAVEAI GELHSDAAIP GLLCALEDES YCVYKRAVEA LGKLGSEAAI TVLFQVLENQ
     DPARCLHAAE ALWHFSLNAT ILGLIESLKN PHFFVRWSAV QALEKIGLET AIIGTIEGLK
     DRSFLIRWYS LEILWQISLN IEIFDLLHFF ENYESSEWEY LKELYKDQCK EKLIMGFLKD
     LDRPEYFLRW SAVKALGKLP SKTGIPGLVK SLKDREPLIR LYAIQALCNQ SLEAGMLGAI
     EGINDPDICV RLYAMKALEE LGSEVAIPGF LQTLGHEDSL VRQRAAEVLG KLGSEVAIPG
     LLSALEDEDF WVRKSAVEAL GELGSEAAIP GLLNALKDKY SDVRESAVKA LGKLSSEAAI
     PGLLSALEDE DSRVRESAVK ALGKLGSEAA IPGLLCALEN EDSRVRESAV KALGKLGSEA
     AIPGLLNALE DESSRVRNSA VEAFGNLKND RAAHILPHLL TLIPTESGES AFRALTAIQA
     NCKFYNYDLF KSPPLPTVPA TPPAVVRYEF HNTEVVTIVE KNNGEVIGKQ ISEAE
//