ID   A0A928WR43_9CYAN        Unreviewed;       903 AA.
AC   A0A928WR43;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   02-APR-2025, entry version 8.
DE   SubName: Full=HDIG domain-containing protein {ECO:0000313|EMBL:MBE9061989.1};
GN   ORFNames=IQ256_13560 {ECO:0000313|EMBL:MBE9061989.1};
OS   cf. Phormidesmis sp. LEGE 11477.
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Leptolyngbyales;
OC   Leptolyngbyaceae; Phormidesmis.
OX   NCBI_TaxID=1828680 {ECO:0000313|EMBL:MBE9061989.1, ECO:0000313|Proteomes:UP000631728};
RN   [1] {ECO:0000313|EMBL:MBE9061989.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LEGE 11477 {ECO:0000313|EMBL:MBE9061989.1};
RA   Castelo-Branco R., Eusebio N., Adriana R., Vieira A.,
RA   Brugerolle De Fraissinette N., Rezende De Castro R., Schneider M.P.,
RA   Vasconcelos V., Leao P.N.;
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBE9061989.1}.
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DR   EMBL; JADEXO010000041; MBE9061989.1; -; Genomic_DNA.
DR   RefSeq; WP_193856075.1; NZ_JADEXO010000041.1.
DR   Proteomes; UP000631728; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   InterPro; IPR052722; PgpH_phosphodiesterase.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000631728};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        477..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        512..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..618
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        630..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          684..845
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
FT   REGION          84..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..119
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  100482 MW;  518DD1A471D24DEB CRC64;
     MRALRHVANR IRQVWKKVVP ASFRRIIVRL KPSSRTLKKK VARRCSPLIN GAQNFLLLGD
     TQPMAKSSLD PVCANAEAHT KGLNGQAAAH ANGSEHTRPR PYLPQSPHHN RRPCARRSTG
     HTLIRSPIGS RRTWMVTLLA VMLLATCFGQ RFYRQPALDV RSIAPQTFYA PANAVVEDRK
     ATESRREAVR SGLVQVLRID PEQTAMAMRS LNTLLQQGRE LRAQAGNPPF LNLETLSQTT
     QDFLFQATEA QWQVVWRLAK KPDLFAAQVQ AIADSTAVPT EAAPNEIDAE LSSLTAIQKF
     ALQELLAYRE LYSLPRLAQL QIRLENRRQQ YQKDIEALAA AANTEGRLLY NYRLFELSEE
     QWSRLETTSR QLLNEMMLQG ISVGTPDDLL RRAIESRVSD EPDPEVKAMT AEFIATSVAP
     NLVVDEERTR QQAERAVGQI DPVMLSVEQG DLIVRASEPI DASDFVLLDY FGLTNRYFNW
     VGLCGFSVLI TCAVAFYLWV DHLQVNQLNQ RDHLLVLLLC LGVSVLAALK VPTIGLPAVG
     LLVGSFYGNA LGVTVIGLLM LILPIGTAIS VIPLVAGAAA ALLGTWIAPQ LRSREEFALL
     GGFVGLSQAI VHFILTLMRL TVAAPLWKSI FIGSALHGVY GIAWSVLALG VSPYLEHFFD
     VVTPIRLAEL ANPNRPLLKR LAAEAPGTFQ HTMFVANLAE SGARALGRNV ELVRAGTLYH
     DIGKMHDPQS FIENQLGGPN KHDEIDDPWI SAGIIRKHVT QGLVMARKYR LPQAVQAFIP
     EHQGDMKISY FYQQAKQRQE KEPSLVVNEA DFSYDGPIPQ SPETGITMLA DSCEAALRSL
     KPEASMDEAY SLVNRILRAR WRSRQLVDSG LSRGDMDIIA SVFIQVWQQH NHKRIEYPKN
     VLV
//