ID A0A934KA96_9BACT Unreviewed; 612 AA.
AC A0A934KA96;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MBJ7599428.1};
GN ORFNames=JF922_15290 {ECO:0000313|EMBL:MBJ7599428.1};
OS Candidatus Nephthysia bennettiae.
OC Bacteria; Bacillati; Candidatus Dormiibacterota; Candidatus Dormibacteria;
OC Candidatus Dormibacterales; Candidatus Dormibacteraceae;
OC Candidatus Nephthysia.
OX NCBI_TaxID=3127016 {ECO:0000313|EMBL:MBJ7599428.1, ECO:0000313|Proteomes:UP000612893};
RN [1] {ECO:0000313|EMBL:MBJ7599428.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC8812_S17_10 {ECO:0000313|EMBL:MBJ7599428.1};
RA Montgomery K.;
RT "Ca. Dormibacterota MAGs.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBJ7599428.1}.
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DR EMBL; JAEKNR010000154; MBJ7599428.1; -; Genomic_DNA.
DR RefSeq; WP_338202918.1; NZ_JAEKNR010000154.1.
DR AlphaFoldDB; A0A934KA96; -.
DR Proteomes; UP000612893; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBJ7599428.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000612893}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 612 AA; 65466 MW; EF779749D4B5E580 CRC64;
MSFVVGTAGH IDHGKSTLIQ ALTGIDPDRL EEEKRRGMTI DLGFAYLTLP SGRLVGIVDV
PGHARFIKNM LAGVHGLDAV LLVVAADEGV MPQTREHLEI VDLLEVTRGL AVVTKVDLVE
ADWLELVCAE VSETLAGTSL AGAEILAVSA ETGQGLEELK LRLDALLDAT PARQDRGRPR
LPVDRVFTIG GFGTVVTGTL VDGSLRVGEE LDLQPSARRV RVRGLQQHNR KVEVAQPGSR
VAANLVGVEK DELGRGEVLA RPGTLVATRR VDASVRVLSD SPRGVRHGAQ VILHTGTAEV
PARVIVLAAD EIAPGTSGWV QLYLAHPLAV VPGDRFVLRL PSPSVTIAGG AFADVNPRRH
PRHDERVPES LERRLAGEVL QEELRKYPRG ITEAALLRAT LADGADASHL QARRAGQWLF
APEAWAGLAA RAGEVLEEYH RAHPLRAGMP RQEMKSRLGL APAAFGPVLA ALVQEGVLGE
RAGELALPQH RVEIEPAAGG PAGRLLELLG RRPFAPPSLP EAMRDSGASA EVVRALARAG
ELVRLSEDVA FTPSAYADAL ELVKEIVAGE GSVTVASLRD RLGASRRPVL ALLEYLDAQR
ITRRLGDARV LR
//
