ID A0A936ZEJ0_9BURK Unreviewed; 646 AA.
AC A0A936ZEJ0;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MBL0420099.1};
GN ORFNames=JI739_07035 {ECO:0000313|EMBL:MBL0420099.1};
OS Ramlibacter aurantiacus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Comamonadaceae; Ramlibacter.
OX NCBI_TaxID=2801330 {ECO:0000313|EMBL:MBL0420099.1, ECO:0000313|Proteomes:UP000613011};
RN [1] {ECO:0000313|EMBL:MBL0420099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AW1 {ECO:0000313|EMBL:MBL0420099.1};
RA Kang M.;
RT "Ramlibacter sp. strain AW1 16S ribosomal RNA gene Genome sequencing and
RT assembly.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBL0420099.1}.
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DR EMBL; JAEQNA010000001; MBL0420099.1; -; Genomic_DNA.
DR RefSeq; WP_201683089.1; NZ_JAEQNA010000001.1.
DR AlphaFoldDB; A0A936ZEJ0; -.
DR Proteomes; UP000613011; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBL0420099.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000613011}.
FT DOMAIN 1..169
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 646 AA; 68752 MW; 43F4A9005CBD4564 CRC64;
MIVAVCGHVD HGKTRLVHAL TGVDTDRLPE EKRRGMTIEP GFAHLEAGPE PLGFADVPGH
EGFLRQAIVG LAASDAALLV VACDDGPMPQ TREHLDLLQL LGITRGVVAL TKTDRVAPER
VAQVRAAVQA LVRGTALSGA PLFEVSAARG DGVGELREAL LALQADTPAS EPHGGFRLAV
DRAFSRAGAG TVATGTVISG QVRAGDTLVL SPAGSPHRVR GVQRAGTAVD VVRAGQRCAI
ALPGAPREQL ARGTWLVDPA LHAPTLRLDV RLRLLPSAPR PLEGHAQAQL HIGAAALPAR
LLLLQPLRLE PGEEGWAQVQ LQAPVSALHG DRFVLRDPSA HALLGGGVVL DDAPPLRSRR
GGARLAELAA LQDDDAARVL GRLLELRPGG VDLAVFARQW NLQPERMDAI RQGLDARAVA
MPHGPRLVSE SAWRALVEAV PRVVDDWHRD HPSRVGIGES ALLRALPAAS GHRADEAPLR
QAAIRAAVAD GLLVRDGFLL RRPGHQARLD PQDAALVERV RALLQPTGLR PPPLGELAAL
LELPVEEASA ALARVAGMGH VVQVARNRYF LPETVHALMA VARETAAAAP EGWFDAASFR
DRSGVGRNLT IQLLEFFDRI GFTRYRAERR VIAGDPDQKA GRLEGR
//
