ID A0A937D1K4_9BURK Unreviewed; 650 AA.
AC A0A937D1K4;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MBL0420619.1};
GN ORFNames=JI739_09715 {ECO:0000313|EMBL:MBL0420619.1};
OS Ramlibacter aurantiacus.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Comamonadaceae; Ramlibacter.
OX NCBI_TaxID=2801330 {ECO:0000313|EMBL:MBL0420619.1, ECO:0000313|Proteomes:UP000613011};
RN [1] {ECO:0000313|EMBL:MBL0420619.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AW1 {ECO:0000313|EMBL:MBL0420619.1};
RA Kang M.;
RT "Ramlibacter sp. strain AW1 16S ribosomal RNA gene Genome sequencing and
RT assembly.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBL0420619.1}.
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DR EMBL; JAEQNA010000002; MBL0420619.1; -; Genomic_DNA.
DR RefSeq; WP_201683683.1; NZ_JAEQNA010000002.1.
DR AlphaFoldDB; A0A937D1K4; -.
DR Proteomes; UP000613011; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBL0420619.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000613011}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 650 AA; 68670 MW; A2B2B0A4C4F8C378 CRC64;
MIVATAGHID HGKTLLVRTI TGVDTDRLPE EKARGISIDL GFAYGSPGGG PLIGFVDVPG
HERFVRNMVA GVCGIDFALV VVAADDGVMP QTVEHVQILD LLQVRAGLVV MTKIDRADAA
RRAQVRGQID ALLAGTTLAG LRTVEASPLT GEGMDAVVSA LCAAAGATPE RWQPGHHFRF
AVDRAFTIDG SGTVVTGTVF SGEAAIGDRL LASPGGLAAR VRRLRVHAQE VERVRAGDRC
AINLAGMSLE DVSRGDWIVT AAVHRPSSRL DVALRLLPGA QLPGPAARVH LHHGCRHVMA
RVVPIAAAPA SGPGGPGLAR LIVDEPLPAL HGDRFIVRDP TAQRTLGGGV VLDPFTRVRG
GRAQRLATLE ALARPGVGQA LAGLLESPAG VDLDRFELMF NLAPPATQAL LDALGVVVIG
RQPRIGITRE RHALWERATH ACLEAFHAQH PAVTGMRIKE LRDRVEPSLA LPAFEALLHA
GSLSRRVAMR NGVARLAEHD VAANPADRAL WEAVYPLLRG AGGSIASALP RTQELAQAAR
VDPRALAEML YRRRAAGMVH RVGADRFCLR TTLSALATTA GAVARSSPDG SFTVAQFRDA
IGTGRGLAIE ILECLDGVGA TRRVGEVRRM RDEHLHLLED PPAAAPACAR
//
