ID A0A940MYA4_9PROT Unreviewed; 725 AA.
AC A0A940MYA4;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:MBP0491960.1};
GN ORFNames=J5Y10_04120 {ECO:0000313|EMBL:MBP0491960.1};
OS Roseomonas indoligenes.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Acetobacterales; Roseomonadaceae; Roseomonas.
OX NCBI_TaxID=2820811 {ECO:0000313|EMBL:MBP0491960.1, ECO:0000313|Proteomes:UP000677537};
RN [1] {ECO:0000313|EMBL:MBP0491960.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SG15 {ECO:0000313|EMBL:MBP0491960.1};
RA So Y.;
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBP0491960.1}.
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DR EMBL; JAGIZA010000002; MBP0491960.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A940MYA4; -.
DR Proteomes; UP000677537; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR FunFam; 3.40.1440.10:FF:000001; UvrABC system protein C; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR050066; UvrABC_protein_C.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; NF001824; PRK00558.1-5; 1.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF22920; UvrC_RNaseH; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 2.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Hydrolase {ECO:0000313|EMBL:MBP0491960.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000677537};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 29..107
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 217..252
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 268..540
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 693..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..708
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 79894 MW; 9EBEB1D3CDE7F1F6 CRC64;
MAFSNEQTTP LAPMEGREVI ERALLTLPFS PGVYRMLDAK GDALYVGKAR SLKKRVYAYT
QVHKLPDRLK RMVFETRHLE VITTASEAEA LLLEANLIKR LRPRYNIVLR DDKSYPWLVI
TEDHPYPQIS KHRGERRKGA SYWGPFASAW AVNQTLTALQ RVFLLRSCRD TVFDNRSRPC
LLHQIRRCSA PCVERVSKEE YGELVKEATQ FLSGETPSIQ KRLAKEMEEA AERLEFERAA
AIRDRIRGLT HVQGRDRINM ENVGDADVVA LHMAAGQACV QVFFFRGGRN NGNRPFFLSG
MRADAEPAEV VTAFLGQLYD DLPPPPLVLV SHELPEAALV AEALSLRGDR RVEVHHPKRG
DKRSAVEHAQ TNAREALERK LAEGAAQGEL LEGVAKIFDL SSTPERIEIY DNSHIQGTNA
YGVMVVAGPS GFLKNAYRKF SIRGEGVVPA KGREPADATG TEPLAGEDVA ALAHDAAGRT
ALKSTGGPRG GDDFAMMREV FERRFGRALK EDPERESDTW PDLVLIDGGL GQLNAAREIL
TEMGIHDIPL VAVAKGPDRD AGREWFHRTG HDPIQLPPRD PVLYYLQRLR DEAHRFAITT
HRAGRSKSLV KSELDDIPGV GTAIKRALLN HFGSARGVRN AALEDLQNTP GIGPSVAKRI
YEHFHPGTTG PLEPLRPRGG RRKAAALDAI AEAPDAVPGA VPDAVAEEPP SPPLAADAAG
HEVEG
//
