ID A0A942U619_9BACI Unreviewed; 523 AA.
AC A0A942U619;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=KHA99_13995 {ECO:0000313|EMBL:MBS4213562.1};
OS Neobacillus rhizophilus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Neobacillus.
OX NCBI_TaxID=2833579 {ECO:0000313|EMBL:MBS4213562.1, ECO:0000313|Proteomes:UP000679749};
RN [1] {ECO:0000313|EMBL:MBS4213562.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FJAT-49825 {ECO:0000313|EMBL:MBS4213562.1};
RA Liu G.;
RT "Novel Bacillus species.";
RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBS4213562.1}.
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DR EMBL; JAGYPF010000003; MBS4213562.1; -; Genomic_DNA.
DR RefSeq; WP_213118108.1; NZ_JAGYPF010000003.1.
DR Proteomes; UP000679749; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR InterPro; IPR039506; SPOB_a.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43547:SF10; SENSOR HISTIDINE KINASE DCUS; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF14689; SPOB_a; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF55890; Sporulation response regulatory protein Spo0B; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:MBS4213562.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000679749};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..523
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 523 AA; 58880 MW; 38E87A12D35DD907 CRC64;
MNRLSIQTKI TALIFFIVSF SLLLAGIIVI SNFINTEEAE LQKRALLSAQ TIAEDVGIKS
NITGSMEDRV KIRKRVETLR IIHHADYIVV MDMNHIRLSH PLPSLIGKRS NGSDEGPAFA
ELTYTTKAKG EVGTMIRAFV PIMNEEHQQV GVVLAGYKLP TFFEMIWDLR MEILFAGFIS
LLFGGWGSWL FASKMKKQMF NLEPHEIAQL VQERTETFNA MHEGIIAIDK DEKITIFNDK
AKTMMGISGD VIGRSIAEVV PDTRLPEILE LKKPIYNKEL TVRNLNIHSN RIPIKANNEI
IGALAIFQDR TEVKKLAEEL TGFKAFVSAL RVQNHEHMNK LHTIAGLLQL GNPKKALEYV
FQTAEEQEEL TQFLSKNIKS ESLSGLMISK VSRAKELGIH LHIDRNSRLH SFPEPLDEHD
FVIIIGNLIE NAFDSYRNKE IDEKNIYVSI EHDEEILSIL VEDNGSGIPE NVLPHIFTKG
FSTKDSLDHG IGLYLIKEIV DRAGGTIQVE SDLGKGTTFI VTI
//
